过硫酸铵促进喹喔啉-2(1H)-酮三氟甲基化反应  

Ammonium Persulfate Promotes Trifluoromethylation of Quinoxalin-2(1H)-ones

作　　者：易荣楠 刘冬娴[1] 贺江南[1] 赵明明[1] 许新华[2] Yi Rongnan;Liu Dongxian;He Jiangnan;Zhao Mingming;Xu Xinhua(Department of Criminal Technology,Hunan Police Academy,Changsha 410138;State Key iMboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082)

机构地区：[1]湖南警察学院刑事科学技术系,长沙410138 [2]湖南大学化学化工学院化学传感与计量学国家重点实验室,长沙410082

出　　处：《有机化学》2021年第8期3285-3291,共7页Chinese Journal of Organic Chemistry

基　　金：湖南省科技重大专项(NO.2014FJ1010);湖南省自然科学基金(NO.2018JJ2019)资助项目.

摘　　要：报道了温和条件下,过硫酸铵促进喹喔啉-2(1H)-酮与CF3SO2Na三氟甲基化制备3-三氟甲基喹喔啉-2(1H)-酮类的反应,开发了一种绿色、高效制备3-三氟甲基喹喔啉-2(1H)-酮衍生物的方法.该方法对不同取代的喹喔啉-2(1H)-酮衍生物具有较好的适用性,均以较高的产率得到相应的目标产物.与已有方法相比,本方法具有底物适用范围广、产率高、实验操作简便等优点,为3-三氟甲基喹喔啉-2(1H)-酮的制备提供了有效的路径.A green and efficient method for the synthesis of 3-trifluoromethylquinoxalin-2(1 H)-ones via direct trifluoromethylation of quinoxalin-2(1 H)-ones with CF3 SO2 Na promoted by ammonium persulfate((NH4)2 S2 O8) under mild conditions has been developed. This process is scalable and tolerates a wide spectrum of quinoxalin-2(1 H)-one derivatives to deliver corresponding products in good to excellent yields. Comparing to the previous methods, this strategy has the advantages of wide functional groups tolerance, high yield and simple operation, providing an efficient synthetic approach to 3-trifluoromethylquinoxalin-2(1 H)-ones.

关 键 词：过硫酸铵 三氟甲基化 喹喔啉-2(1H)-酮衍生物 三氟甲基亚磺酸钠 

分 类 号：O626[理学—有机化学]