骨植入医用钛合金表面改性涂层研究进展  

Research Progress of Surface Modification Coatings on Titanium Alloys for Bone Implants

作　　者：唐萍 江少群[1,2] 王刚 TANG Ping;JIANG Shaoqun;WANG Gang(College of Mechanics and Materials,Hohai University,Nanjing 211100,China;Ocean and Offshore Engineering Research Institute of Hohai University,Nantong 226019,China)

机构地区：[1]河海大学力学与材料学院,江苏南京211100 [2]南通河海大学海洋与近海工程研究院,江苏南通226019

出　　处：《中国材料进展》2021年第8期631-638,共8页Materials China

基　　金：南通市市级科技计划项目(JC2018113);中央高校基本科研业务费项目(2017B16114,B200205001)。

摘　　要：钛合金具有优良的力学性能以及良好的生物相容性,使其广泛应用于骨植入生物医药领域。随着植入物性能要求的不断提高,力学性能优异的高强模比新型医用钛合金逐渐被开发,同时,由于钛合金存在表面细胞粘附性差等骨整合问题,通过表面改性来提升钛合金生物相容性成为医用钛合金的研究焦点。概述了骨植入医用钛合金的发展历程和常用的表面改性涂层技术,侧重介绍了羟基磷灰石(hydroxyapatite,HA)涂层、壳聚糖涂层以及利用阳极氧化法在钛合金表面制备的TiO 2纳米管阵列涂层。总结了涂层结构、晶型、离子掺杂等对钛合金表面润湿性、细胞增殖分化的影响规律。指出在新型低弹性模量钛合金上,通过制备表面改性涂层和多种表面改性方法结合,提高植入物的骨整合能力以及实现功能化是未来医用钛合金表面改性的主要方向。Titanium alloys have been widely used in the field of biomedicine due to their excellent mechanical properties and good biocompatibility.With the continuous improvement of performance requirements for implants,new medical titanium alloys with excellent mechanical property and high strength modulus ratio have been gradually developed.At the same time,due to the osseointegration problems of titanium alloys such as poor surface cell adhesion,surface modification to improve the biocompatibility of titanium alloys has become the research focus of medical titanium alloys.This article summarized the development progress of biomedical titanium alloy for bone implants and common surface modification coatings,focusing on the introduction of hydroxyapatite(HA)coating,chitosan coating and the TiO 2 nanotube array coating on the surface of titanium alloy prepared by anodic oxidation.The effect of microstructure,crystal type and ion doping,etc.on the surface wettability,cell proliferation and differentiation of titanium alloy was summarized.It was pointed out that improving the osseointegration ability of implants and achieving functionalization of the new low elastic modulus titanium alloy by preparing surface modification coatings or combining a variety of surface modification methods would be the main direction of alloy surface modification of future medical titanium alloys.

关 键 词：钛合金 表面改性 生物相容性 阳极氧化 TiO 2纳米管 羟基磷灰石 

分 类 号：TG146.2[一般工业技术—材料科学与工程]