血府逐瘀汤加减对乙肝肝硬化失代偿期肝纤维化及炎性因子的影响  

Effect of Xuefu Zhuyu Decoction on liver fibrosis and inflammatory factors in decompensated stage of hepatitis B cirrhosis

作　　者：刘巍[1] 韩涛[2] LIU Wei;HAN Tao(Tieling Hospital of Traditional Chinese Medicine,Tieling 112000,China;the Theory and Application of Traditional Chinese Medicine Visceral Manifestations key Laboratory of the State Ministry of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]铁岭市中医医院,辽宁铁岭112000 [2]辽宁中医药大学中医脏象理论及应用国家教育部重点实验室,辽宁沈阳110032

出　　处：《实用药物与临床》2021年第9期821-825,共5页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨血府逐瘀汤加减对乙肝肝硬化失代偿期肝纤维化及炎性因子的影响。方法选择2018年11月-2019年4月我院乙肝肝硬化失代偿期患者74例,按随机对照原则平均分为2组,对照组选择保肝、利尿及对症支持治疗;在此基础上,观察组选择血府逐瘀汤加减治疗,每日1剂,持续治疗24周。比较两组血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、Ⅲ型前胶原肽(PC-Ⅲ)、IV型胶原(IV-C)、层粘蛋白(LN)、透明质酸(HA)、丙氨酸氨基转移酶(ALT)、谷氨酸氨基转移酶(AST)、Child-Pugh评分及临床疗效。结果与治疗前相比,两组治疗后血PC-Ⅲ、IV-C、LN、HA、TNF-α、IL-6、ALT、AST及Child-Pugh评分均降低;与对照组相比,观察组治疗后血PC-Ⅲ、IV-C、LN、HA、TNF-α、IL-6、ALT、AST及Child-Pugh评分较低,差异有统计学意义(P<0.05)。对照组有效率78.38%,低于观察组(94.59%),差异有统计学意义(P<0.05)。两组不良反应轻微,经对症处理后消失,对研究无影响。结论血府逐瘀汤加减对乙肝肝硬化失代偿期的疗效确切,可降低肝纤维化和炎症因子,提高肝功能,安全性高。Objective To investigate the effect of Xuefu Zhuyu Decoction on liver fibrosis and inflammatory factors in decompensated cirrhosis of hepatitis B.Methods A total of 74 patients with decompensated hepatitis B cirrhosisl treated in our hospital from November 2018 to April 2019 were randomly divided into two groups.The control group was treated with routine liver protection, diuresis and symptomatic support treatment;on this basis, the observation group was treated with Xuefu Zhuyu Decoction, 1 dose a day, continuously for 24 weeks as a course of treatment.Compare tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),procollagen Ⅲ(PC-Ⅲ),collagen IV(IV-C),laminin(LN),hyaluronic acid(HA),alanine aminotransferase(ALT),aspartate transaminase(AST),Child-Pugh score and the clinical efficacy between the two groups.Results Compared with before treatment, the PC-Ⅲ,IV-C,LN,HA,TNF-α,IL-6,ALT,AST and Child-Pugh scores in the two groups were decreased after treatment;compared with the control group, the PC-Ⅲ,IV-C,LN,HA,TNF-α,IL-6,ALT,AST and Child-Pugh scores in the observation group were lower(P<0.05).The effective rate of the control group(78.38%) was lower than that of the observation group(94.59%)(P<0.05).The adverse reaction was mild in both groups, and disappeared after symptomatic management, so it didn′t affect the study.Conclusion The modified Xuefu Zhuyu Decoction has definite curative effect on decompensated hepatitis B cirrhosis, reduces liver fibrosis and inflammatory factors and improves liver function, and it is worthy of promotion.

关 键 词：血府逐瘀汤 乙肝肝硬化失代偿期 纤维化 炎性因子 

分 类 号：R259[医药卫生—中西医结合]