丙泊酚输注综合征1例分析  

Analysis of one case of propofol infusion syndrome

作　　者：林志豪 姚慧娟[1] 陆晓彤[1] 张健[1] LIN Zhi-hao;YAO Hui-juan;LU Xiao-tong;ZHANG Jian(Department of Pharmacy,Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Department of Pharmacy,Dongguan Kanghua Hospital,Dongguan 523080,China)

机构地区：[1]上海交通大学医学院附属新华医院药学部,上海200092 [2]东莞康华医院药学部,广东东莞523080

出　　处：《实用药物与临床》2021年第9期861-864,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨丙泊酚输注综合征的早期识别。方法分析发生于我院的1例丙泊酚输注综合征病例,探讨丙泊酚输注综合征的临床表现和特点。结果患者使用丙泊酚后出现了代谢性酸中毒、心电图改变、横纹肌溶解伴急性肾损伤、转氨酶及乳酸升高等临床症状,考虑为丙泊酚输注综合征。结论丙泊酚输注综合征为严重的药源性疾病,疾病死亡率高。如患者在使用丙泊酚时出现代谢性酸中毒、横纹肌溶解、ECG改变中的一种或多种症状需警惕。用药期间监测血酸碱度、乳酸、肌酸激酶和心电图是早期识别疾病的关键。Objective To research the early diagnosis of propofol infusion syndrome.Methods To study the symptoms of propofol infusion syndrome by analyzing a patient who was diagnosed with propofol infusion syndrome.Results After propofol was administered,the patient had metabolic acidosis,ECG changes,rhabdomyolysis with acute kidney injury and elevated transaminase and lactate.The patient was diagnosed with propofol infusion syndrome.Conclusion Propofol infusion syndrome is a severe drug-induced disease with high mortality.Clinicians should consider propofol infusion syndrome in case of one or more symptoms of metabolic acidosis,ECG changes and rhabdomyolysis.To monitor pH,creatine kinase,lactate and ECG is the key to the early diagnosis of propofol infusion syndrome.

关 键 词：丙泊酚 丙泊酚输注综合征 药物不良反应 横纹肌溶解 

分 类 号：R614[医药卫生—麻醉学]