支气管镜下局部治疗联合全身抗结核治疗支气管结核疗效分析  

Analysis of the efficacy of bronchoscopic local treatment combined with systemic anti-tuberculosis in the treatment of bronchial tuberculosis

作　　者：程耀强[1] 陀子能[1] CHENG Yao-qiang;TUO Zi-neng(Gaozhou People’s Hospital,Gaozhou 525200,China)

机构地区：[1]高州市人民医院,525200

出　　处：《中国实用医药》2021年第26期28-31,共4页China Practical Medicine

摘　　要：目的探讨支气管结核患者采取支气管镜下局部治疗联合全身抗结核治疗的临床疗效。方法60例支气管结核患者,随机分为单一组和联合组,每组30例。单一组接受全身抗结核治疗,联合组在单一组基础上接受支气管镜下局部治疗。比较两组临床治疗效果、不良反应发生情况及治疗后不同时间段痰菌转阴率。结果联合组临床治疗总有效率96.67%高于单一组的80.00%,差异具有统计学意义(P<0.05)。联合组不良反应发生率10.00%(3/30)明显低于单一组的33.33%(10/30),差异具有统计学意义(χ^(2)=4.812,P=0.028<0.05)。联合组治疗后1、2、3个月的痰菌转阴率分别为60.00%(18/30)、80.00%(24/30)、93.33%(28/30),单一组治疗后1、2、3个月的痰菌转阴率分别为33.33%(10/30)、46.67%(14/30)、73.33%(22/30);联合组治疗后1、2、3个月的痰菌转阴率均明显高于单一组,差异具有统计学意义(χ^(2)=4.286、7.177、4.320,P=0.038、0.007、0.038<0.05)。结论支气管结核患者采取支气管镜下局部治疗联合全身抗结核治疗能有效提升临床治疗效果和痰菌转阴率,降低不良反应发生率,疗效确切,具有较高的临床推广和应用价值。Objective To discuss the clinical efficacy of bronchoscopic local treatment combined with systemic anti-tuberculosis in the treatment of bronchial tuberculosis.Methods A total of 60 patients with bronchial tuberculosis were randomly divided into single group and combination group,with 30 cases in each group.The single group received systemic anti-tuberculosis treatment,and the combination group received bronchoscopic local treatment on the basis of the single group.The clinical effect,occurrence of adverse reactions,and sputum negative-conversion rate at different time periods after treatment were compared between the two groups.Results The total effective rate of the combination group was 96.67%,which was higher than 80.00%of the single group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 10.00%(3/30)in the combination group was significantly lower than 33.33%(10/30)in the single group,and the difference was statistically significant(χ^(2)=4.812,P=0.028<0.05).The sputum negative-conversion rate of the combination group at 1,2,3 months of treatment were 60.00%(18/30),80.00%(24/30)and 93.33%(28/30),which were 33.33%(10/30),46.67%(14/30)and 73.33%(22/30)of the single group.The sputum negative-conversion rate of the combination group at 1,2,3 months of treatment were obviously higher than those of the single group,and the difference was statistically significant(χ^(2)=4.286,7.177,4.320;P=0.038,0.007,0.038<0.05).Conclusion Combined bronchoscopic local treatment and systemic anti-tuberculosis has definite efficacy on patients with bronchial tuberculosis,and it can effectively improve the total clinical effectiveness and sputum negativeconversion rate,reduce the incidence of adverse reactions,which has high clinical promotion and application value.

关 键 词：支气管结核 支气管镜 局部治疗 全身抗结核 疗效 

分 类 号：R523[医药卫生—内科学]