主观认知下降患者不同BMI水平与执行功能的相关性研究  

Correlation between different BMI levels and executive function in patients with subjective cognitive decline

作　　者：徐姝蕊 罗佳[1] 陈瑞琳 蔡桂燕 刘娇[1,2,3,4] XU Shu-rui;LUO Jia;CHEN Rui-lin;CAI Gui-yan;LIU Jiao(College of Rehabilitation Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China;不详)

机构地区：[1]福建中医药大学康复医学院,福建福州350122 [2]福建省康复技术重点实验室 [3]福建中医药大学康复产业研究院 [4]中医骨伤及运动康复教育部重点实验室

出　　处：《现代预防医学》2021年第17期3247-3253,共7页Modern Preventive Medicine

基　　金：国家自然科学基金项目(81904270);福建省自然科学基金科研项目(2019J01362);福建省教育厅高校杰出青年科研人才培育计划项目(闽教科[2018]47号);福建省科技厅科技平台建设项目(2015Y2001)。

摘　　要：目的探讨主观认知下降(SCD)患者不同BMI水平与执行功能之间的相关性,及影响BMI的危险因素。方法招募福建省福州市5个社区符合要求的174例SCD患者,根据BMI水平分为正常体质量组(18.5kg/m^(2)≤BMI<24kg/m^(2))、超重和肥胖组(24kg/m^(2)≤BMI≤36.5kg/m^(2)),并进行问卷调查、身体测量和Stroop色词测验。采用单因素分析比较不同BMI水平SCD患者执行功能,采用二元logistic回归模型分析影响SCD患者BMI的危险因素。结果与正常体质量组相比,超重和肥胖组Stroop干扰量(SIE)反应时更长,差异有统计学意义(P<0.05)。二元logistic回归分析发现,男性患超重和肥胖的风险高于女性(OR=2.204, 95%CI:1.086~4.475,P=0.029),高血压患者患超重和肥胖的概率是无高血压患者的3.060倍(OR=3.060, 95%CI:1.194~7.838,P=0.020)。结论与正常体质量组相比,超重和肥胖的SCD患者执行功能更差,而且受性别和高血压的影响。对男性SCD患者,控制高血压和体重可能可以有效预防其执行功能下降,降低患AD的风险。Objective To explore the correlation between different BMI levels and executive function in patients with subjective cognitive decline, and the risk factors affecting BMI. Methods A total of 174 patients with SCD who met the requirements from 5 communities in Fuzhou, Fujian were recruited and divided into normal body mass group(18.5 kg/m^(2)≤BMI<24 kg/m^(2)), overweight and obesity group(24 kg/m^(2)≤BMI≤36.5 kg/m^(2)) according to their BMI level. The questionnaire survey, body measurement and Stroop Color Word Test were conducted. Univariate analysis was used to compare the executive function of SCD patients with different BMI levels, and binary logistic regression model was used to analyze the risk factors affecting BMI in SCD patients. Results Compared with the normal body mass group, the overweight and obesity group had longer Stroop Interfere Effects(SIE) response time, and the difference was statistically significant(P<0.05). Binary logistic regression analysis found that the risk of overweight and obesity in men was higher than that in women(OR= 2.204, 95%CI:1.086-4.475,P=0.029), and the probability of overweight and obesity in patients with hypertension was 3.060 times of patients without it(OR= 3.060, 95%CI:1.194-7.838,P=0.020). Conclusion Compared with SCD patients with normal body mass, overweight and obese SCD patients have worse executive function and are affected by gender and hypertension. In men with SCD, controlling hypertension and weight may be effective in preventing the decline of executive function and reducing the risk of AD.

关 键 词：主观认知下降 体质量指数 超重 肥胖 执行功能 

分 类 号：R589.2[医药卫生—内分泌]