广西河池市单中心IMN患者血清CA125浓度升高的相关因素分析  

Analysis the Correlative Factors of Elevated Serum Concentrations of CA-125 in Patients with Idiopathic Membranous Nephropathy:A Retrospective Single-center Study of Hechi City

作　　者：齐东丽[1] 韦喆 万启军[1] 岑吉 胡豪飞 程媛 覃勋 QI Dong-li;WEI Zhe;WAN Qi-jun;CEN Ji;HU Hao-fei;CHENG Yuan;QIN Xun(Shenzhen Second People’s Hospital,The First Affi liated Hospital of Shenzhen University,Guangdong Shenzhen 518035;The People’s Hospital of Hechi,Hechi Hospital Affi liated to Youjiang Medical College For Nationalities,Guangxi Hechi 547000)

机构地区：[1]深圳市第二人民医院深圳大学第一附属医院,广东深圳518035 [2]河池市人民医院右江民族医学院附属河池医院,广西河池547000

出　　处：《深圳中西医结合杂志》2021年第14期1-4,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：深圳市卫生健康委员会医学重点学科建设项目资助课题(SZXK009);河池市科学研究与技术开发计划项目资助课题(B1824-9)。

摘　　要：目的:探讨特发性膜性肾病(IMN)患者血清糖类抗原125(CA125)浓度升高的相关因素。方法:本研究为单中心回顾性横断面研究,连续纳入2013年6月至2021年3月在河池市人民医院住院并经肾活检确诊为IMN的患者,按照血清CA125浓度是否升高分为阳性组(>35 U·mL^(-1))、正常组(≤35 U·mL^(-1))。采用单因素及多因素Logistic回归分析影响IMN患者CA125升高的相关因素。结果:共有295例患者入选本研究,两组比较发现,阳性组患者的舒张压、血肌酐浓度、总胆固醇浓度、低密度脂蛋白浓度、血CA153浓度、尿蛋白定量、血清M型磷脂酶A2受体(PLA2R)抗体、肾病综合征、浆膜腔积液均较高(均P<0.05),而其血清白蛋白浓度、估算的肾小球滤过率(eGFR)、血清免疫球蛋白G(IgG)浓度均较低;肾脏病理特征为阳性组的肾小球节段性硬化、肾小管急性亚急性损伤的比例均较阴性组明显升高,差异均具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示:浆膜腔积液〔OR=7.54,95%CI(2.70,21.01),P=0.0001〕、低密度脂蛋白浓度〔OR=1.44,95%CI(1.04,1.99),P=0.0281〕是IMN患者中血清CA125升高的独立危险因素。结论:在IMN患者中,血清CA125浓度升高与浆膜腔积液、低密度脂蛋白浓度独立相关。Objective To investigate the related factors of elevated serum CA125 concentration in patients with idiopathic membranous nephropathy(IMN).Methods It was a single-center retrospective cross-sectional study.The patients with biopsyproven IMN who were hospitalized in Hechi People's Hospital from June 2013 to March 2021 were included.Patients were divided into two groups on the basis of serum CA125 concentrations:positive group(>35 U/ml),normal group(≤35 U/ml).Univariate and multivariate logistic regression were used to analyze the related factors of serum CA125 elevation in IMN patients.Results There were 295 patients included in this study.Compared with the normal group,patients in positive group exhibited higher levels of diastolic blood pressure,serum creatinine concentration,total cholesterol concentration,low density lipoprotein concentration,serum CA153 concentration,urinary protein level as well as serum PLA2R antibody(all P<0.05),and a lower level of serum albumin concentration,eGFR and serum IgG concentration(all P<0.05),and had higher proportions of nephrotic syndrome,serosal cavity effusion,Acute and Subacute Renal Insults,segmental glomerular sclerosis(all P<0.05),Multivariate logistic regression analysis showed that Serosal effusion(OR 1.44,95%CI(1.04,1.99),0.0281)and low density lipoprotein concentration(OR 1.44,95%CI(1.04,1.99),0.0281)were independent risk factors for elevated serum CA125 of IMN.Conclusion In IMN patients,the increase of serum CA125 concentration was independently associated with serosal effusion and low density lipoprotein concentration.

关 键 词：特发性膜性肾病 血清糖类抗原125 浆膜腔积液 

分 类 号：R692[医药卫生—泌尿科学]