HMGB1在慢性阻塞性肺疾病中的临床意义  

Explore the Signifi cance of HMGB1 in Chronic Obstructive Pulmonary Disease

作　　者：于恪 黄建林[1] 李国萍 袁丽芬[1] 邓海燕[1] YU Ke;HUANG Jian-lin;LI Guo-ping;YUANG Li-fen;DENG Hai-yan(Shenzhen Second People’s Hospital,the First Affi liated Hospital of Shenzhen University,Guangdong Shenzhen 518035)

机构地区：[1]深圳市第二人民医院深圳大学第一附属医院,广东深圳518035

出　　处：《深圳中西医结合杂志》2021年第14期5-8,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨血清高迁移率族蛋白B1(HMGB1)在慢性阻塞性肺疾病(COPD)中的意义。方法:选取深圳市第二人民医院2019年1月1日至2019年12月31日呼吸内科收治的COPD急性加重期患者42例,分析COPD急性加重期与COPD临床缓解期患者血清HMGB1、超敏C反应蛋白(hs–CRP)及肺功能的差异性及相关性;应用受试者工作特征曲线(ROC)分析HMGB1对COPD急性加重期的诊断价值。结果:(1)COPD急性加重期患者的血清HMGB1、hs–CRP水平高于临床缓解期,第1秒用力呼气容积占预计值百分比(FEV1%)低于临床缓解期,差异具有统计学意义(P均<0.001);(2)COPD急性加重期患者HMGB1与hs–CRP呈正相关(r=0.778,P<0.001),HMGB1与FEV1%不相关(r=–0.117,P=0.460);(3)COPD临床缓解期患者HMGB1与hs–CRP呈正相关(r=0.361,P=0.019),HMGB1与FEV1%呈负相关(r=–0.678,P<0.001);(4)ROC曲线分析结果显示,HMGB1对COPD急性加重具有较好的诊断价值,ROC曲线下的面积(AUC)为0.761,灵敏度为66.7%,特异度为83.3%,阳性预测值80.0%,阴性预测值71.4%。结论:HMGB1参与局部气道炎症及全身炎症反应过程,对COPD急性加重的预测及病情严重程度的评估都具有重要的意义。Objective To investigate the significance of serum high mobility group box protein B1(HMGB1)in chronic obstructive pulmonary disease(COPD).Methods We selected 42 patients with acute exacerbation of COPD who were admitted to the department of respiratory medicine at Shenzhen second people’s hospital from January 1,2019 to December 31,2019.To analyze the difference and correlation of serum HMGB1,high-sensitivity C-reactive protein(hs-CRP)and lung function in patients with acute exacerbation of COPD and clinical remission of COPD;The receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of HMGB1 in the acute exacerbation of COPD.Results(1)The expression levels of serum HMGB1 and hs–CRP in the acute exacerbation stage of COPD were higher than those in the clinical remission stage,and the predicted value of FEV1%in the acute exacerbation stage was lower than that in the clinical remission stage(all P<0.001);(2)HMGB1 was positively correlated with hs–CRP in the acute exacerbation of COPD(r=0.778,P<0.001),HMGB1 was not correlated with the predicted value of FEV1%(r=-0.117,P=0.460);(3)HMGB1 was positively correlated with hs–CRP in the clinical remission stage of COPD(r=0.361,P=0.019),HMGB1 was negatively correlated with FEV1%(r=-0.678,P<0.001);(4)ROC curve analysis shows that HMGB1 has a good diagnostic value for acute exacerbations of COPD,with AUC of 0.761,sensitivity of 66.7%,specifi city of 83.3%,positive predictive value of 80%,negative predicted value of 71.4%.Conclusion HMGB1 participates in the process of local airway infl ammation and systemic infl ammatory response,and is of great signifi cance for the prediction of acute exacerbations of COPD and the evaluation of the severity of the disease.

关 键 词：慢性阻塞性肺疾病 高迁移率族蛋白B1 超敏C反应蛋白 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]