rTMS联合盐酸哌罗匹隆、奥氮平治疗新发性精神分裂症临床研究  

Clinical Study of rTMS Combined with Piperopilone Hydrochloride and Olanzapine in the Treatment of Emerging Schizophrenia

作　　者：赵斌斌 何燕飞[1] 陈硕勋[1] ZHAO Bin-bin;HE Yan-fei;CHEN Shuo-xun(Zhaoqing Third People's Hospital,Guangdong Zhaoqing 526060)

机构地区：[1]肇庆市第三人民医院,广东肇庆526060

出　　处：《深圳中西医结合杂志》2021年第14期14-16,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：肇庆市科技创新指导类项目资助课题(201904031453)。

摘　　要：目的:探究不同方案治疗新发性精神分裂症的临床疗效与安全性。方法:选取肇庆市第三人民医院2017年2月至2019年4月期间收治的108例新发性精神分裂症患者,随机分为A组、B组和C组,各36例。A组采用重复经颅磁刺激(rTMS)治疗,B组采用rTMS联合盐酸哌罗匹隆治疗,C组采用rTMS联合奥氮平治疗。比较三组疗效、认知功能变化和不良反应情况。结果:B组和C组治疗总有效率比较,差异无统计学意义(P>0.05);B组和C组治疗总有效率高于A组,差异具有统计学意义(P<0.05)。治疗前三组患者的Loewenstein评定表评分比较,差异无统计学意义(P>0.05)。治疗后B组和C组Loewenstein评定表评分比较,差异无统计学意义(P>0.05);治疗后B组和C组患者Loewenstein评定表评分高于A组,差异具有统计学意义(P<0.05)。B组和C组不良反应发生率比较,差异无统计学意义(P>0.05);B组和C组不良反应发生率低于A组,差异具有统计学意义(P<0.05)。结论:rTMS联合抗精神疾病药物的治疗方案能提高疗效,改善认知功能,降低不良反应发生,安全性较高。Objective To explore the clinical efficacy and safety of different regimens in the treatment of new-onset schizophrenia.Methods A total of 108 patients with newly diagnosed schizophrenia admitted to The Third People’s Hospital of Zhaoqing city from February 2017 to April 2019 were randomly divided into group A,group B and group C,with 36 patients in each group.Group A received repetitive transcranial magnetic stimulation (rTMS),group B received rTMS combined with piperopilon hydrochloride,and group C received rTMS combined with Olanzapine.The curative effect,cognitive function changes and adverse reactions of the three groups were compared.Results There was no significant difference in the total effective rate between group B and group C (P>0.05).The total effective rate of group B and C was higher than that of group A,and the difference was statistically significant (P<0.05).There was no significant difference in Loewenstein scale score among the three groups before treatment (P>0.05).After treatment,there was no significant difference in Loewenstein scale score between group B and group C (P>0.05).After treatment,Loewenstein scale score of group B and C was higher than that of group A,and the difference was statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between group B and GROUP C (P>0.05).The incidence of adverse reactions in group B and C was lower than that in group A,with statistical significance (P<0.05).Conclusion rTMS combined with antipsychotic drugs can improve the efficacy,improve cognitive function,reduce the occurrence of adverse reactions,and have high safety.

关 键 词：新发性精神分裂症 重复经颅磁刺激 奥氮平 盐酸哌罗匹隆 

分 类 号：R749.3[医药卫生—神经病学与精神病学]