热毒宁注射液辅助治疗对急性胆囊炎术后患者炎症指标及免疫功能的影响  

Effect of adjuvant Reduning injection on inflammatory reaction and immune function in patients with acute cholecystitis after operation

作　　者：陈佳骏[1] 张海阳[1] 曲岩 曹学冬[1] 宋鑫 CHEN Jiajun;ZHANG Haiyang;QU Yan;CAO Xuedong;SONG Xin(Department of Hepatobiliary Surgery,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China)

机构地区：[1]上海中医药大学附属曙光医院肝胆外科,上海201203

出　　处：《临床急诊杂志》2021年第8期540-543,共4页Journal of Clinical Emergency

摘　　要：目的:探讨热毒宁注射液(下称热毒宁)辅助治疗对急性胆囊炎术后患者炎症指标及免疫功能的影响。方法:将2020年1月-2020年6月期间在本院接受腹腔镜胆囊切除术治疗的急性胆囊炎患者纳入研究,采用随机数字表法将患者随机分为热毒宁干预组和对照组。两组患者均接受手术及预防性抗感染等常规治疗,热毒宁干预组患者加用热毒宁注射液干预,比较两组患者体温改善时长、炎症指标、淋巴细胞亚群及不良反应发生率的差异。结果:热毒宁干预组患者更快恢复至正常体温(P<0.05)。热毒宁干预组患者治疗2 d后,血液中CD3+、CD4+淋巴细胞水平增高更显著,CD8+淋巴细胞水平下降更明显,且血清CRP、PCT水平更低,与对照组比较,差异均具有统计学意义(P<0.05)。热毒宁注射液的应用不增加不良反应的发生率(P>0.05)。结论:在腹腔镜胆囊切除及预防性抗感染治疗等常规治疗基础上,加用热毒宁注射液可有效缩短急性胆囊炎患者体温恢复至正常水平的时间,其机制可能与抑制炎症反应并改善患者免疫状态相关。Objective:To investigate the effect of adjuvant Reduning injection on inflammatory indexes and immune function in patients with acute cholecystitis after surgery.Methods:The patients with acute cholecystitis who underwent laparoscopic cholecystectomy in our hospital from January 2020 to June 2020 were included in the present study,and the patients were randomly divided into the Reduning intervention group and the control group using a random number table method.Both groups of patients received conventional treatments such as surgery and preventive anti-infection.Patients in the Reduning intervention group were treated with Reduning injection.The duration of temperature improvement,inflammation indicators,lymphocyte subsets and incidence of adverse reactions were compared between the two groups.Results:The patients in the Reduning intervention group recovered to normal body temperature faster(P<0.05).After 2 days of treatment in the Reduning treatment group,level of CD3+and CD4+lymphocytes in the blood increased more significantly,level of CD8+lymphocytes decreased more significantly,and the serum CRP and PCT levels were lower.The differences compared with the control group were statistically significant(P<0.05).Reduning application did not increase the incidence of adverse reactions(P>0.05).Conclusion:On the basis of conventional treatment such as laparoscopic cholecystectomy and prophylactic use of antibiotics,Reduning intervention can effectively shorten the time length for recovering to normal temperature in patients with acute cholecystitis after operation,and its mechanism may be related to inhibite inflammatory reaction and improve immune status of patients.

关 键 词：热毒宁 急性胆囊炎 炎症因子 免疫功能 

分 类 号：R285.6[医药卫生—中药学]