不同程度尼古丁依赖者的动态功能网络连接研究  

Evaluation of Dynamic fMRI Network Connectivity in Different Levels of Nicotine Addicts

作　　者：许珂[1] 张勇[1] 程敬亮[1] 时园园 汪卫建 XU Ke;ZHANG Yong;CHENG Jingliang(the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,P.R.China)

机构地区：[1]郑州大学第一附属医院磁共振科,450052 [2]焦作市第二人民医院,454150

出　　处：《临床放射学杂志》2021年第7期1256-1261,共6页Journal of Clinical Radiology

摘　　要：目的通过独立成分分析方法导出的血氧水平依赖的时间序列在窗口分段上计算的相关矩阵,并进一步应用滑动窗相关法探索尼古丁依赖者动态功能连接指标的组间差异。方法在Matlab平台上对所采集的121名尼古丁依赖者(尼古丁依赖组)以及58名不吸烟的志愿者(对照组)的功能磁共振数据分别进行预处理,并将经过预处理的数据分为80个成分进行组水平上的独立成分分析,共得到27个有效的独立成分;通过滑动时间窗技术对27个有效的独立成分进行动态功能连接分析。结果尼古丁依赖组和对照组的时间分数在state 2和state 3状态下、平均停留时间在state 3状态下具有组间差异(P<0.05),而转换次数在各个state中无统计学差异(P>0.05),在state 1和state 4状态下两组间的三项功能连接指标(时间分数、平均停留时间、转换次数)均无统计学差异(P>0.05)。对照组和轻度尼古丁依赖组的时间分数在state 2、state 3和平均停留时间在state 2均存在差异(P<0.05);对照组和重度尼古丁依赖组的平均停留时间在state 2存在差异(P<0.05);轻度尼古丁依赖组和重度尼古丁依赖组的三项功能连接指标的组间比较均无统计学差异(P>0.05)。结论尼古丁依赖者存在全脑功能网络连接异常的现象,主要表现为整体网络连接效率降低,部分局部网络连接效率提高。吸烟时间的长短、尼古丁依赖的程度对大脑功能连接有直接的影响,吸烟时间越长对全脑弱功能连接状态的影响越大,尼古丁依赖的程度越大则对全脑功能网络连接较强的状态的影响就越大且维持在该状态下的时间越长。Objective This study adopts the sliding window correlation method and the correlation matrix calculated on the window segment of the BOLD time series derived by the independent component analysis method.The purpose of this study was to explore the differences of dynamic functional connectivity indexes of nicotine dependent patients.Methods Matlab platform was used to preprocess the collected fMRI data(121 nicotine addict(mean age 35.87±7.66)and 58 nonsmoking volunteers(mean age 34.27±6.47)),the preprocessed data were divided into 80 components for independent component analysis at the group level,and a total of 27 effective independent components are obtained,the dynamic functional connection analysis of 27 effective independent components was carried out by sliding time window technology.Results The dynamic functional connectivity indexes were compared between the nicotine addict group and the non-smoking control group:there was significant difference in the fraction time of the state 2 and state 3 and the mean dwell time of the state 3 between the nicotine addict group and the non-smoking control group(P<0.05),but there was no significant difference in the numbers of transitions between the two groups(P>0.05).There was no significant difference in the three functional connection indexes between the two groups in the state 1 and state 4(P>0.05).There were significant differences in fraction time of state 2,state 3 and mean dwell time of state 2 between non-smoking control group and mild nicotine addict group(P<0.05).There were significant differences in mean dwell time of state 2 between normal control group and severe nicotine addict group(P<0.05).Conclusion In this study,it was found that nicotine addict patients have abnormal whole brain functional network connection,which is mainly manifested by the decrease of overall network connection efficiency and the improvement of partial local network connection efficiency.The length of smoking time and the degree of nicotine addict have a direct effect on the brai

关 键 词：尼古丁依赖 功能磁共振影像 动态功能网络连接 

分 类 号：R163[医药卫生—公共卫生与预防医学]