顺苯磺酸阿曲库铵、异丙酚及七氟醚联合麻醉对老年腹腔镜手术患者术后认知功能的影响  

Effects of cisatracurium,propofol and sevoflurane anesthesia on postoperative cognitive function in elderly patients undergoing laparoscopic surgery

作　　者：马兴对 闫龙剑 吴靓 姚莹莹 李秀芳[1] 王德领[1] 李北平[1] Ma Xingdui;Yan Longjian;Wu Liang;Yao Yingying;Li Xiufang;Wang Deling;Li Beiping(Dept.of Anesthesiology,Xuzhou First People's Hospital,Xuzhou 221116,China)

机构地区：[1]徐州市第一人民医院麻醉科,江苏徐州221116

出　　处：《山东第一医科大学（山东省医学科学院）学报》2021年第8期595-597,共3页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：徐州市科技计划项目(KC18030)。

摘　　要：目的观察顺苯磺酸阿曲库铵、异丙酚与七氟醚配伍麻醉对老年腹腔镜手术患者术后认知功能的影响。方法对照组予以瑞芬太尼配伍异氟醚以及咪唑安定麻醉,研究组则予以泵注顺苯磺酸阿曲库铵、异丙酚与七氟醚麻醉,对比两组术后的苏醒状况、疼痛VAS评分以及认知功能MMSE评分变化情况。结果研究组老年患者的睁眼、定向力恢复时间以及自主呼吸恢复时间均显著短于对照组,差异有统计学意义(t=4.476、3.921、6.730,P<0.05);对比发现,研究组老年患者认知功能MMSE评分在麻醉前与对照组差异无统计学意义(P>0.05);术后2 h、12 h、24 h,研究组患者的MMSE评分相较对照组升高更为明显,且在术后12 h,认知功能MMSE评分趋近于术前状态,且与对照组比较差异有统计学意义(P<0.05);研究组术后不同时间点的VAS评分均低于对照组,差异有统计学意义(P<0.05)。结论顺苯磺酸阿曲库铵、异丙酚与七氟醚三种不同麻醉药物配伍使用能够明显改善患者术后认知功能,加快患者恢复。Objective:To discuss the effect of the compatibility of cisatracurium,propofol and sevoflurane on postoperative cognitive function in elderly patients undergoing laparoscopic surgery.Method Control group to rui fentanyl compatibility isoflurane and imidazole stable anesthesia,the team is pump injection along the benzene sulfonic acid cisatracurium,propofol and sevoflurane anesthesia,the postoperative recovery status,pain VAS score and cognitive function MMSE score changes were compared between the two groups.Results:The directional power recovery,eye opening and spontaneous breathing time of the elderly patients in the study group were significantly shorter than those in the control group,with statistically significant differences(t=4.476,3.921,6.730,P<0.05).Compared with the control group,there was no significant difference in MMSE score of cognitive function between the study group and the control group before anesthesia(P>0.05).At 2 h,12 h and 24 h postoperatively,MMSE scores of patients in the study group were more significantly increased than those in the control group,and 12 h postoperatively,MMSE scores of cognitive function were close to the preoperative status,with statistically significant differences from the control group(P<0.05);The VAS scores of the study group at different time points after operation were lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion:Cisatracurium cisplatin and sevoflurane,three different anesthetic drugs,can significantly improve postoperative cognitive function and speed up the recovery of patients.

关 键 词：顺苯磺酸阿曲库铵 异丙酚 七氟醚 老年 腹腔镜手术 认知功能 

分 类 号：R614[医药卫生—麻醉学]