幼儿急疹合并热性惊厥发病与HHV-6和HHV-7感染的关系  

Correlation between HHV-6,HHV-7 and the pathogenesis of exanthema subitum complicated by febrile convulsions

作　　者：刘展 LIU Zhan(Department of Pediatric,Mentougou District Hospital,Beijing 102300,China)

机构地区：[1]首都医科大学门头沟教学医院/北京市门头沟区医院儿科,102300

出　　处：《河北医药》2021年第18期2800-2803,共4页Hebei Medical Journal

基　　金：国家卫生健康委医药卫生科技发展研究中心(编号:WA2020HK29)。

摘　　要：目的探讨幼儿急疹合并热性惊厥临床发病与疱疹病毒HHV-6型和HHV-7型感染的相互关系。方法选取2019年1月至2019年7月幼儿急疹、幼儿急疹合并热性惊厥各20例,选取其他疾病患儿为其他疾病组进行PCR检测疱疹病毒HHV-6型和HHV-7型,分析疱疹病毒感染与幼儿急疹的关系。同时记录幼儿急疹的临床特征和辅助检查结果。结果20例幼儿急疹合并热性惊厥患儿中HHV-6型阳性17(85%)例,HHV-7型阳性5(25%)例。20例幼儿急疹患儿中HHV-6型阳性13(65%)例,HHV-7型阳性4(20%)例。以HHV-6、HHV-7感染单因素分析,幼儿急疹组患儿所占比例明显高于其他疾病组患儿(P<0.01);合并热性惊厥组患儿和未合并热性惊厥组患儿组间比较,差异无统计学意义(P>0.05)。所有患儿均存在发热症状,其最典型的特征为热退疹出;高热(T≥39℃)的30例(75.00%);外周血白细胞<4.0×10^(9)/L共15例(37.50%),(4.0~9.5)×10^(9)/L共19例(47.50%),>9.5×10^(9)/L共6例(15.00%)。结论幼儿急疹患儿均存在发热症状,以热退疹出为典型临床症状,幼儿急疹的发病与疱疹病毒感染密切相关,但与合并热性惊厥发生无相关性。Objective To investigate the correlation between HHV-6,HHV-7 and the pathogenesis of exanthema subitum complicated by febrile convulsions.Methods Twenty patients with exanthema subitum and 20 patients with exanthema subitum complicated by febrile convulsions who were treated in our hospital from January 2019 and Junuary 2019 were enrolled in the study,and the patients with the other diseases were enrolled as control group.The HHV-6 and HHV-7 were detected by PCR,and the correlation between the herpes virus infection and exanthema subitum was analyzed.Moreover the clinical characteristics and the results of auxiliary examinations were analyzed.Results Of the 20 infants with the 20 infants with exanthema subitum complicated by febrile convulsions,there were 7 cases(85%)of positive HHV-6 and 5 cases(25%)of positive HHV-7.Among the 20 infants with exanthema subitum,there were 13 cases(65%)of positive HHV-6 and 4 cases(20%)of positive HHV-7.The univariate analysis showed that the proportion of HHV-6 and HHV-7 in the two case group was significantly higher than that in control group(P<0.01).However there was no significant difference between the two case groups(P>0.05).The fever was common symptoms,and 30cases(75.00%)had high fever(T≥39℃).The typical symptoms of exanthema subitum were fever and rash.The WBC<4.0×10^(9)/L was in 15 cases(37.50%)and(4.0~9.5)×10^(9)/L was in 19 cases(47.50%),and the WBC>9.5×10^(9)/L was in 6 cases(15.00%).Conclusion All the infants with exanthema subitum have fever symptoms,and the typical symptoms were fever and rash.Herpesvirus infection is closely related to the pathogenesis of exanthema subitum,however,which is not associated with febrile convulsion.

关 键 词：幼儿急疹 热性惊厥 疱疹病毒 PCR检测 感染 单因素分析 

分 类 号：R758.64[医药卫生—皮肤病学与性病学]