抗HBV天然化合物作用机制的研究进展  

Research advance in anti-HBV natural products and their mechanism of action

作　　者：相佳瑶 许敏[1] 冯阳[1] XIANG Jia-yao;XU Min;FENG Yang(Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650000, China)

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650000

出　　处：《中国药理学通报》2021年第10期1346-1351,共6页Chinese Pharmacological Bulletin

基　　金：国家基金自然科学基金资助项目(No 31960093,81973210);云南省教育厅创新团队和Ronald J Quinn AM院士工作站(No 2019IC003)。

摘　　要：乙型肝炎病毒(hepatitis B virus,HBV)感染是世界性的公共卫生问题。虽然疫苗能有效预防HBV的感染,但是对已感染HBV的患者无效。现在临床上应用的抗HBV药物主要有干扰素和核苷(酸)类似物两类,但是干扰素治疗存在较大的不良反应,而长期使用核苷(酸)类似物会引起HBV耐药以及停药复发的问题。因此,迫切需要找到新的抗HBV药物和新的治疗机制。天然来源的化合物具有结构复杂性和多样性的特点,是发现具有新的抗病毒机制和新靶点的抗HBV先导化合物的源泉。该文从天然化合物调控HBV自身因子和调控宿主因子两方面,总结了近年来天然产物抗HBV作用机制的研究进展,以期为抗乙肝病毒药物的研究和开发提供一定的参考。Hepatitis B virus(HBV)infection is still a major public health problem worldwide.The vaccine can effectively prevent HBV infection.However,it is not valid for patients infected with HBV.Interferon-α(IFN-α)and nucleoside(acid)analogues are clinically useful anti-HBV drugs.However,IFN-αhas substantial side effects,and long-term use of nucleoside(acid)analogues may cause problems of HBV resistance and relapse.Therefore,it is of urgent need to develop new anti-HBV drugs,especially the drugs with new mechanism of action.Natural products are one of the main resources of discovering anti-HBV leading compounds due to structural complexity and diversity.This review summarizes the recent research advance in mechanisms of anti-HBV natural products.Special emphasis is given to modulating virus factors and host factors.It is hopeful that our summary may bring out some good idea with the development of new anti-HBV drugs.

关 键 词：乙型肝炎病毒 生命周期 天然产物 作用机制 药物靶点 研究进展 

分 类 号：R282.71[医药卫生—中药学] R284.1[医药卫生—中医学]