多孔钽生物学特性及其在修复ONFH、CSD的研究进展  

Advances in biological characteristics of porous tantalum and its progress in repairing ONFH and CSD

作　　者：敖玉(综述) 蒋电明(审校) AO Yu;JIANG Dianming(Department of Orthopedics,the Third Affiliated Hospital of Chongqing Medical University,Chongqing 401120,China)

机构地区：[1]重庆医科大学附属第三医院骨科,401120

出　　处：《重庆医学》2021年第18期3215-3218,3224,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81472057)。

摘　　要：股骨头缺血性坏死(ONFH)和临界骨缺损(CSD)是骨科临床治疗的难题。多孔钽具有高孔隙率、高摩擦系数和低弹性模量的特点,其优良的生物相容性、生物活性及骨整合能力使其在治疗ONFH及关节置换术后翻修骨缺损中临床疗效优良,但高昂的价格及苛刻的制作工艺限制其广泛应用。国产多孔钽打破美国制造垄断,多孔钽支架负载种子细胞或(和)细胞因子修复CSD取得令人振奋的结果。目前,国产多孔钽修复CSD处于动物实验阶段,尚需解决梯度材料的一体化制备难题,从而解决高力学强度与高孔隙率间的矛盾,其巨大的优势和潜力不可小觑,有望成为修复CSD的理想植入材料之一。Osteonecrosis of the femoral head(ONFH)and critical size defect(CSD)are major difficult problems in clinical treatment of orthopedics.Porous tantalum is characterized by high porosity,high friction coefficient and low elastic modulus.Due to its excellent biocompatibility,biological activity and bone integration ability,porous tantalum has excellent clinical efficacy in the treatment of ONFH and bone defects after joint replacement.However,its high price and rigorous production process limit its wide application.Domestic porous tantalum has broken the manufacturing monopoly in the United States,and the porous tantalum scaffold has achieved exciting results in the repair of CSD with seed cells or(and)cytokines.At present,domestic porous tantalum repair CSD is in the stage of animal experiments,and the problem of integrated preparation of gradient materials still needs to be solved,so as to solve the contradiction between high mechanical strength and high porosity.Its huge advantages and potential cannot be underestimated,and it is expected to become one of the ideal implant materials for CSD repair.

关 键 词：多孔钽 临界骨缺损 支架材料 股骨头缺血坏死 综述 

分 类 号：R687.1[医药卫生—骨科学]