早期应用氯吡格雷对NSTE-ACS患者介入治疗心脏不良事件发生率及近期预后的影响  

Influence of Early Clopidogrel on the Incidence of Adverse Cardiac Events and Short-Term Prognosis in NSTE-ACS Patients with Interventional Therapy

作　　者：李颖珂[1] LI Yingke(Department of Cardiology,the First Affiliated Hospital of He'nan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院心内科,河南洛阳471000

出　　处：《临床医学工程》2021年第9期1251-1252,共2页Clinical Medicine & Engineering

摘　　要：目的探讨早期应用氯吡格雷对非ST段抬高性急性冠脉综合征(NSTE-ACS)患者介入治疗心脏不良事件发生率及近期预后的影响。方法选取2019年3月至2020年3月我院收治的80例拟行介入治疗的NSTE-ACS患者,随机分为对照组(n=40)和观察组(n=40)。对照组在冠脉造影后口服氯吡格雷治疗,观察组入院后即服用氯吡格雷治疗。比较两组患者的心脏不良事件发生率、近期预后。结果两组的冠脉病变及支架治疗情况比较无统计学差异(P>0.05)。观察组的心脏不良事件发生率为2.50%,低于对照组的17.50%(P<0.05)。治疗前,两组的hs-CRP、TNF-α、NT-proBNP水平比较无统计学差异(P>0.05);治疗后,观察组的hs-CRP、TNF-α、NT-proBNP水平低于对照组(P<0.05)。结论在NSTE-ACS患者介入治疗后早采用氯吡格雷治疗,可明显降低心脏不良事件发生率,缓解心肌炎症,从而改善患者的近期预后。Objective To explore the effect of early clopidogrel on the incidence of adverse cardiac events and short-term prognosis in patients with non-ST elevation acute coronary syndrome(NSTE-ACS)undergoing interventional therapy.Methods 80 NSTE-ACS patients who will received interventional therapy in our hospital from March 2019 to March 2020 were selected and randomly divided into control group(n=40)and observation group(n=40).The control group was treated with clopidogrel after coronary angiography,and the observation group was treated with clopidogrel after admission.The incidence of adverse cardiac events and short-term prognosis of the two groups were compared.Results No statistical difference was found in the coronary artery disease and stent treatment between the two groups(P>0.05).The incidence of adverse cardiac events in the observation group was 2.50%,lower than 17.50%in the control group(P<0.05).Before treatment,no statistical difference was found in the hs-CRP,TNF-αand NT-proBNP levels between the two groups(P>0.05).After treatment,the hs-CRP,TNF-αand NT-proBNP levels of the observation group were lower than those of the control group(P<0.05).Conclusions Early clopidogrel in NSTE-ACS patients after interventional therapy can significantly reduce the incidence of adverse cardiac events,alleviate the myocarditis,and improve the short-term prognosis of patients.

关 键 词：非ST段抬高性急性冠脉综合征 氯吡格雷 介入治疗 心脏不良事件 

分 类 号：R541.4[医药卫生—心血管疾病]