短节段后路腰椎融合术中静脉使用氨甲环酸的疗效及安全性的meta分析  被引量:3

Meta-analysis of the efficacy and safety of intravenous Tranexamic Acid in short-segment posterior lumbar interbody fusion

在线阅读下载全文

作  者:谢家豪 郭海威 王羽丰[2] 陈博来[2] 傅妙玲 杨清淇 XIE Jiahao;GUO Haiwei;WANG Yufeng;CHEN Bolai;FU Miaoling;YANG Qingqi(The Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou510000,China;the First Department of Orthopedics,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangdong Province,Guangzhou510000,China;Department of Otolaryngology,Meizhou Hospital of Traditional Chinese Medicine,Guangdong Province,Meizhou514000,China;the Second Clinical Medical College,Guangzhou Medical University,Guangdong Province,Guangzhou510000,China)

机构地区:[1]广州中医药大学第二临床医学院,广东广州510000 [2]广东省中医院骨一科,广东广州510000 [3]广东省梅州市中医医院耳鼻喉科,广东梅州514000 [4]广州医科大学第二临床医学院,广东广州510000

出  处:《中国医药导报》2021年第27期75-79,共5页China Medical Herald

基  金:国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015081);广东省中医药局科研项目(20193007)。

摘  要:目的系统评价短节段后路腰椎融合术中静脉使用氨甲环酸的疗效及安全性。方法以“氨甲环酸”+“腰椎融合”为关键词,计算机检索PubMed、Embase、Medline、Cochrane Library、CNKI、CBM、VIP、Wanfang Data等数据库自建库至2020年12月的随机对照试验。实验组为静滴氨甲环酸,对照组为静滴生理盐水,比较两组总失血量、术中出血量、术后引流量、输血率及深静脉血栓事件发生率,采用RevMan 5.3软件进行meta分析。结果共纳入6篇文献,共包含557例患者,meta分析结果显示,实验组总失血量(MD=-280.88,95%CI:-309.18,-252.59,P<0.00001),术中出血量(MD=-73.34,95%CI:-128.52,-18.15,P=0.009),术后引流量(MD=-150.29,95%CI:-211.48,-89.10,P<0.00001),输血率(OR=0.32,95%CI:0.19,0.52,P<0.00001)均低于对照组。两组深静脉血栓事件发生率比较,差异无统计学意义(P>0.05)。结论短节段后路腰椎融合术中静脉使用氨甲环酸疗效明确,安全可靠,但需更多高质量的随机对照试验进一步证实。Objective To systematically evaluate the efficacy and safety of intravenous Tranexamic Acid in short-segment posterior lumbar interbody fusion.Methods Randomized controlled trial from PubMed,Embase,Medline,Cochrane Library,CNKI,CBM,VIP,Wanfang and other self-built databases up to December 2020 were searched using the keywords“trantranic acid”and“lumbar fusion”.The experimental group was intravenous Tranexamic Acid,and the control group was intravenous normal saline.Total blood loss,intraoperative blood loss,postoperative drainage,blood transfusion rate and incidence of deep venous thrombosis events were compared between the two groups.Meta-analysis was performed using RevMan 5.3 software.Results A total of six literatures were included,including 557 patients.Meta-analysis results showed that total blood loss(MD=-280.88,95%CI:-309.18,-252.59,P<0.00001),intraoperative blood loss(MD=-73.34,95%CI:-128.52,-18.15,P=0.009),postoperative drainage volume(MD=-150.29,95%CI:-211.48,-89.10,P<0.00001),transfusion rate(OR=0.32,95%CI:0.19,0.52,P<0.00001)in the experimental group were lower than the control group.There was no significant difference in the incidence of deep vein thrombosis events between the two groups(P>0.05).Conclusion Intravenous Tranexamic Acid is effective and safe in short-segment posterior lumbar interbody fusion,but it needs more high-quality randomized controlled trial to confirm.

关 键 词:氨甲环酸 后路腰椎融合术 短节段 随机对照 META分析 

分 类 号:R681.53[医药卫生—骨科学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象