丙种球蛋白小剂量静注治疗典型与不完全川崎病患儿的临床疗效比较  

Comparison of the clinical efficacy of low-dose intravenous gamma globulin in treatment of children with typical and incomplete Kawasaki disease

作　　者：何丽影 叶红[1] HE Li-ying;YE Hong(Department of General Pediatrics,Lianjiang People′s Hospital,Guangdong 524440,China)

机构地区：[1]廉江市人民医院普通儿科,广东524440

出　　处：《中国临床新医学》2021年第9期900-903,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：湛江市科技计划项目(编号:2020B01087)。

摘　　要：目的比较丙种球蛋白小剂量静注治疗典型与不完全川崎病患儿的临床疗效。方法选择2018年2月至2020年5月廉江市人民医院收治的川崎病患儿86例,按疾病类型不同分为不完全川崎病组(不完全组,52例)和典型川崎病组(典型组,34例)。两组均采用常规治疗(包括雾化化痰、物理降温、营养支持等),在此基础上使用小剂量静脉滴注丙种球蛋白(1 g/kg)+口服阿司匹林治疗。比较两组住院时间、血液指标、冠状动脉病变发生率。结果不完全组住院时间为(8.07±0.46)d,典型组为(10.70±0.39)d,两组比较差异有统计学意义(t=27.486,P=0.000)。治疗后,不完全组C反应蛋白(CRP)、血小板、白细胞、血沉水平均显著低于典型组(P<0.05)。与治疗前比较,两组治疗后冠状动脉病变发生率均显著下降(P<0.05),而不完全组显著低于典型组(P<0.05)。结论丙种球蛋白小剂量静注治疗不完全川崎病患儿的效果优于典型川崎病患儿,能够缩短住院时间,改善血液指标,降低冠状动脉病变发生率。Objective To compare the clinical efficacy of low-dose intravenous gamma globulin in the treatment of children with typical and incomplete Kawasaki disease.Methods From February 2018 to May 2020,86 children with Kawasaki disease who were admitted to Lianjiang People′s Hospital were selected and divided into incomplete Kawasaki disease group(incomplete group,52 cases)and typical Kawasaki disease group(typical group,34 cases)according to different types of the disease.Both groups were treated with conventional treatments(including nebulization for reducing phlegm,physical cooling and nutritional support).On this basis,low-dose intravenous infusion of gamma globulin(1 g/kg)+oral aspirin was used.The length of hospital stay,blood indexes,and the incidence of coronary artery disease were compared between the two groups.Results The length of hospital stay in the incomplete group was(8.07±0.46)days,and that in the typical group was(10.70±0.39)days,and the difference was statistically significant between the two groups(t=27.486,P=0.000).After treatment,the levels of C-reactive protein(CRP),platelets,white blood cells,and erythrocyte sedimentation in the incomplete group were significantly lower than those in the typical group(P<0.05).Compared with those before treatment,the incidence rates of coronary artery disease in the two groups decreased significantly after treatment(P<0.05),and the incidence of coronary artery disease in the incomplete group was significantly lower than that in the typical group(P<0.05).Conclusion The effect of low-dose intravenous gamma globulin on the treatment of children with incomplete Kawasaki disease is better than that of children with typical Kawasaki disease.It can shorten the hospital stay,improve blood indexes,and reduce the incidence of coronary artery disease.

关 键 词：不完全川崎病 典型川崎病 丙种球蛋白 血液指标 

分 类 号：R725.4[医药卫生—儿科]