白细胞介素在银屑病自噬和细胞焦亡中的研究进展  

Research progress of interleukin in autophagy and pyroptosis of psoriasis

作　　者：王悦琪(综述) 周婧(审校)[1] WANG Yueqi;ZHOU Jing(Department of Dermatology and Venereology,Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第二医院皮肤病与性病科,哈尔滨150000

出　　处：《临床与病理杂志》2021年第9期2167-2171,共5页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金(81602753)。

摘　　要：银屑病病因不明。它是一种在多基因遗传背景下的系统疾病的皮肤表现,可由环境、情绪等多种因素共同作用导致发病。多种病因假说支持银屑病的发病机制,其中有关遗传及免疫因素参与发病是更加令人信服的,包括各种免疫细胞和细胞因子等多种因素都参与了银屑病发病机制。几种与银屑病相关的白细胞介素(interleukin,IL)在细胞焦亡和自噬中起重要作用。The etiology of psoriasis is unknown.Psoriasis is a skin manifestation of systemic diseases under the background of polygenetic inheritance,which can be caused by environment,emotion,and other factors.A variety of etiological hypotheses support the pathogenesis of psoriasis,but the involvement of genetic and immune factors in the pathogenesis of psoriasis is more convincing,including a variety of immune cells,cytokines and other factors involved in the pathogenesis of psoriasis.Several kinds of psoriatic-related interleukin play an important role in pyroptosis and autophagy.

关 键 词：银屑病 白细胞介素 自噬 细胞焦亡 

分 类 号：R75[医药卫生—皮肤病学与性病学]