自噬在狼疮性肾炎中的研究进展  

Research progress of autophagy in lupus nephritis

作　　者：魏巍[1] 杨盟 王明奡[1] 刘睿婵(综述)[1] 隋满姝(审校)[1] WEI Wei;YANG Meng;WANG Ming’ao;LIU Ruichan;SUI Manshu(Department of Nephrology,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院肾内科,哈尔滨150001

出　　处：《临床与病理杂志》2021年第9期2187-2192,共6页Journal of Clinical and Pathological Research

摘　　要：狼疮性肾炎(lupus nephritis,LN)是系统性红斑狼疮(systemic lupus erythematosus,SLE)最严重和最常见的并发症之一。针对其潜在机制的研究,有助于认识病因和改进治疗。自噬是细胞内物质被运送到溶酶体或液泡进行降解的细胞过程。基于对自噬及LN各方面的研究,越来越多的证据证明了自噬和LN的关系。Lupus nephritis(LN)is one of the most severe and common complications of systemic lupus erythematosus(SLE).There has been extensive studies on its underlying mechanisms,which helps to gain knowledge about its causes and treatment.Autophagy is a cellular process in which intracellular contents are transported to lysosomes or vacuoles for degradation.There is emerging evidence indicating the relationship between autophagy and LN based on research on various aspects of autophagy and LN.

关 键 词：狼疮性肾炎 自噬 足细胞 信号通路 

分 类 号：R593.242[医药卫生—内科学]