某三甲医院194例药品不良反应回顾性分析  

Retrospective analysis of 194 cases of adverse drug reactions in a third-gade class-a hospital

作　　者：年婧[1] 贺维涛 翟夏[1] 赵重博[3] 柯琼 孙静[3] NIAN Jing;HE Weitao;ZHAI Xia;ZHAO Chongbo;KE Qiong;SUN Jing(the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000;Jingyang County Hospital,Xianyang 713700;Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学第二附属医院,陕西咸阳712000 [2]泾阳县医院,陕西咸阳713700 [3]陕西中医药大学,陕西咸阳712046

出　　处：《临床医学研究与实践》2021年第28期63-65,共3页Clinical Research and Practice

基　　金：陕西省创新能力支撑计划项目(No.S2018-ZC-TD-0062)。

摘　　要：目的分析某三甲医院药品不良反应(ADR)发生特点及相关因素。方法检索国家药品不良反应监测系统中某三甲医院2018年1月至2020年12月上报并已完成评价的194例ADR报告,统计和分析ADR发生类型、ADR患者性别和年龄、给药途径、相关的药品分类、累及系统/器官分布情况。结果ADR发生最多的类型是已知一般(65.98%);女性ADR发生率高于男性。ADR发生年龄段主要为61~80岁,占比为34.02%。静脉滴注的ADR发生率最高,占比为76.80%。抗微生物药物导致的ADR多于其他种类药物;皮肤及其附件是被累及最多的系统/器官。结论ADR的发生与患者年龄、性别、给药途径、药品类别等存在一定相关性,医护人员应重视ADR监测和上报工作,同时加强患者用药教育和监护,更好地保障患者用药安全。Objective To analyze the occurring characteristics and related factors of adverse drug reactions(ADR)in a third-gade class-a hospital.Methods A total of 194 ADR reports reported and evaluated by a third-gade class-a hospital in the national adverse drug reaction monitoring system from January 2018 to December 2020 were retrieved,and the occurrence type of ADR,gender and age of ADR patients,route of administration,relevant drug classification and involved systems/organs distribution were counted and analyzed.Results The most type of ADR was generally known(65.98%);the incidence of ADR in women was higher than that in men.The age of ADR mainly was 61-80 years old,accounting for 34.02%.The incidence of ADR by intravenous drip was the highest,accounting for 76.80%.The ADR caused by antimicrobial drugs were more than that caused by other kinds of drugs;the skin and its accessories was the most involved systems/organs.Conclusion The occurrence of ADR is related to the patient's age,gender,route of administration and drug category.Medical staff should pay attention to ADR monitoring and reporting,and strengthen patient medication education and monitoring to better ensure the patient's medication safety.

关 键 词：药品不良反应 用药安全 监测上报 给药途径 

分 类 号：R969.3[医药卫生—药理学]