类风湿性关节炎伴自身免疫性甲状腺病的临床分析  

Clinical analysis of rheumatoid arthritis with autoimmune thyroid disease

作　　者：刘凤莲 丁志芳 LIU Fenglian;DING Zhifang(Department of Clinical Laboratory,People's Hospital Affiliated to Jiangsu University,Zhenjiang,Jiangsu,212000,China)

机构地区：[1]江苏大学附属人民医院检验科,江苏镇江212000

出　　处：《当代医学》2021年第29期11-13,共3页Contemporary Medicine

基　　金：江苏大学2018年度临床医学科技发展基金项目(自然科学类)(JLY20180002)。

摘　　要：目的研究类风湿性关节炎(RA)伴自身免疫性甲状腺病(AITD)患病率,探讨RA合并AITD临床特征、血清学特点及高危因素。方法回顾性分析2017年1月至2020年8月于本院就诊的62例RA患者的临床资料,依据是否伴发AITD分为AITD组和对照组,比较两组临床特征及血清学指标,筛选RA伴AITD的高危因素。结果62例RA患者中伴发AITD 21例(33.9%),以甲状腺功能减退最常见。AITD甲状腺功能异常率、女性所占比例高于对照组,差异有统计学意义(P<0.05),血清补体C3水平低于对照组,差异有统计学意义(P<0.05)。两组年龄、病程、关节疼痛评分及其他血清指标比较差异无统计学意义。Logistic回归分析显示补体C3是RA合并AITD的独立危险因素[95%CI:0.600(0.212~1.698),P<0.05]。结论RA患者伴AITD发病率较高,补体C3为RA并发AITD的高危因素,临床应重视对RA患者尤其女性甲状腺相关指标的筛查,以早诊断,早干预。Objective To study the prevalence of rheumatoid arthritis(RA)with autoimmune thyroid disease(AITD),and to explore the clinical characteristics,serological characteristics and risk factors of rheumatoid arthritis(RA)with AITD.Methods The clinical information of 62 RA patients treated in our hospital from January 2017 to August 2020 were reviewed.According to whether AITD was associated with AITD,the two groups were divided into AITD group and control group.The clinical characteristics and serological indexes of the two groups were compared,and the high-risk factors of RA with AITD were screened.Results Among 62 RA patients,21(33.9%)cases had AITD,and hypothyroidism was the most common.The abnormal rate of thyroid function and the proportion of women in the AITD,group were higher than those in the control group(P<0.05),and the level of serum complement C3 was lower than that of the control group(P<0.05).There was no significant difference in age,course of disease,joint pain score and other serum indexes between the two groups.Logistic regression analysis showed that complement C3 was an independent risk factor for RA with AITD[95%CI:0.600(0.212-1.698),P<0.05].Conclusion The prevalence of AITD in RA is high.The complement C3 is a high risk factor of RA complicated with AITD,which suggests that we should pay attention to the screening of thyroid related indicators of RA patients,especially women,so as to achieve early diagnosis and early intervention.

关 键 词：类风湿性关节炎 甲状腺自身免疫病 临床分析 

分 类 号：R581[医药卫生—内分泌]