复方阿昔莫司缓释微丸的制备及其释放度考察  

Preparation and Release Characteristics of Atorvastatin Calcium and AcipimoxSustained-Release Pellets

作　　者：陈小伟 Chen Xiaowei(Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276000,China)

机构地区：[1]鲁南制药集团股份有限公司,山东临沂276000

出　　处：《山东化工》2021年第17期61-62,共2页Shandong Chemical Industry

摘　　要：目的:制备复方阿昔莫司缓释微丸并对其体外释放特性进行研究。方法:采用流化床包衣技术制备阿托伐他汀钙速释微丸;挤出滚圆法制备阿昔莫司载药丸芯,以乙基纤维素N-100为缓释包衣材料,流化床包衣技术制备阿昔莫司缓释微丸;高效液相色谱法测定阿托伐他汀钙、阿昔莫司的释放度。结果:阿托伐他汀钙微丸溶出迅速,阿昔莫司缓释微丸具有较好的缓释效果。结论:制备的复方阿昔莫司缓释微丸具有较理想的释放效果。Objective:To prepare compound acipimox sustained-release pellets and investigate the drug release mechanism in vitro.Methods:At first,atorvastatin calcium pellets were prepared by the fluid-bed.Acipimox pellets were prepared by extrusion-spheronization equipment,and then coated by ethylcellulose N-100 and hydroxypropyl cellulose as porogen using the fluid-bed.The dissolution of the pellets were determined by HPLC respectively.Results:Atorvastatin calcium released immediately and the acipimox pellets had a remarkable sustained-release property in vitro.Conclusion:The preprared pellets exhibited more ideal release characteristics in vitro.

关 键 词：阿托伐他汀钙 阿昔莫司 缓释微丸 挤出滚圆法 流化床 

分 类 号：TQ462[化学工程—制药化工] R972[医药卫生—药品]