N,N'-二甲基-5-硝基-2,2'-联咪唑锌(Ⅱ)配合物的合成,表征及与DNA相互作用  

Synthesis,characterization and interaction with DNA of Zn(Ⅱ)complex based on N,N'-dimethyl-5-nitro-2,2'-biimidazole

作　　者：杨莉宁[1] 刘春叶[1] YANG Li-ning;LIU Chun-ye(Department of Pharmacy,Medical University of Xi'an,Xi'an 710021,China)

机构地区：[1]西安医学院药学院,陕西西安710021

出　　处：《化学工程师》2021年第8期6-9,21,共5页Chemical Engineer

基　　金：陕西省科技厅自然科学基金(2020JM-614);陕西省教育厅产业化项目(2019JQ068)。

摘　　要：以直接合成法合成了N,N'-二甲基-5-硝基-2,2'-联咪唑(NO2Me2biim)的锌(Ⅱ)配合物,利用元素分析、红外光谱、紫外-可见光谱、固体荧光光谱、摩尔电导率和热重分析等方法对配合物的组成和结构进行了表征。以电子光谱、荧光光谱和粘度法研究了配体NO2Me2biim及配合物与小牛胸腺DNA(ct-DNA)的相互作用机制,研究表明配体NO2Me2biim和配合物与ct-DNA以嵌插模式进行相互作用。The zinc complex of N,N'-dimethyl-5-nitro-2,2'-biimidazole was synthesized,its structure and composition was characterized by elemental analysis,IR,UV-vis spectral,solid fluorescence spectra,conductivity and thermogravimetric analysis.The interaction of N,N'-dimethyl-5-nitro-2,2'-biimidazole ligand and the complex with calf thymus DNA was examined using spectral analysis and viscosity studies to understand the mode and extent of DNA binding.Results showed that ligand and the complex combined with DNA by embedding intercalation.

关 键 词：N N'-二甲基-5-硝基-2 2'-联咪唑 ZN配合物 与DNA相互作用 

分 类 号：O614[理学—无机化学]