Is the erythropoietin receptor the key to the identification of the central macrophage in erythroblastic islands?  

作　　者：Lionel Blanc Narla Mohandas 

机构地区：[1]Laboratory of Developmental Erythropoiesis,Department of Molecular Medicine and Pediatrics,The Feinstein Institute for Medical Research,Zucker School of Medicine at Hofstra/Northwell,Manhasset,NY 11030,USA [2]Red Cell Physiology Laboratory,New York Blood Center,New York,NY 10065,USA

出　　处：《Blood Science》2020年第1期38-39,共2页血液科学（英文）

基　　金：NIH Grants HL144436(to L.B.);DK032094(to N.M.).

摘　　要：Erythroblastic islands(EBI)are niches for mammalian erythropoiesis.1 They were first identified in 1958 by Marcel Bessis and consist of a group of differentiating erythroblasts surrounding a central macrophage.2 Over the years,a lot of attention has been paid to understand the role of the central macrophage in regulating the differentiation of the maturing erythroblasts within these islands and in defining the surface proteins thatmediate the interaction between the erythroblasts and the centralmacrophage.3–14While some progress has beenmade in these areas of investigation,the definitive identity of this central macrophage and its function is yet to be fully characterized.

关 键 词：macrophage. BLASTIC interaction 

分 类 号：TU8[建筑科学]