血管外膜在冠状动脉粥样硬化发病机制中的新进展  

Recent advances in the pathogenesis of coronary atherosclerosis in the adventitia of arteries

作　　者：王弘宇 田野[1] WANG Hongyu;TIAN Ye(Department of Cardiology,the First Affiliated Hospital,Harbin Medical University,Harbin,Heilongjiang 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科,黑龙江省哈尔滨市150001

出　　处：《中国动脉硬化杂志》2021年第10期896-902,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金重点项目(81530052);国家重大科研仪器研制项目(81727809)。

摘　　要：冠状动脉粥样硬化是一种慢性动脉炎症性疾病,影响着冠状动脉的结构和功能,进而导致一系列心血管事件。近年来,随着对动脉粥样硬化发病机制的深入研究,血管外膜在其中的作用逐渐受到关注。血管外膜由成纤维细胞、祖细胞、免疫细胞、微血管和肾上腺素能神经等构成,其外包绕着血管周围脂肪组织。血管外膜各类组织和细胞具有高度代谢活性,能够“从外向内”调控整个血管壁的结构和功能,参与着动脉粥样硬化的形成。文章综述了血管外膜在冠状动脉粥样硬化发病机制中的新进展。Coronary atherosclerosis is a chronic inflammatory disease that affects the structure and function of coronary arteries,leading to a series of cardiovascular events.In recent years,the study on the pathogenesis of atherosclerosis in the adventitia of coronary arteries has attracted more and more attention.The adventitia is made up of fibroblasts,progenitor cells,immune cells,microvessels and adrenergic nerves,which surround perivascular adipose tissue.All kinds of tissues and cells of the adventitia have high metabolic activity,which can regulate the structure and function of the whole vascular wall“from the outside to the inside”and participate in the formation of atherosclerosis.This paper reviews the recent advances in the pathogenesis of coronary atherosclerosis in the adventitia of arteries.

关 键 词：动脉外膜 动脉粥样硬化 血管周围脂肪组织 发病机制 

分 类 号：R5[医药卫生—内科学]