分泌卷曲相关蛋白4结构特征及其对脂质代谢的作用  

The structural characteristics of secreted frizzled related protein 4 and its effect on lipid metabolism

作　　者：关华 郑慧媛[3] 王兰[3] 余琦 徐礼鲜 徐仓宝 GUAN Hua;ZHENG Huiyuan;WANG Lan;YU Qi;XU Lixian;XU Cangbao(Shaanxi Key Laboratory of Ischemic Cardiovascular Disease,Institute of Basic and Translational Medicine,Xi'an Medical University,Xi'an,Shaanxi 710021,China;Department of Anesthesiology,Air Force Medical University Stomatological Hospital,Xi'an,Shaanxi 710032,China;Department of Histology and Embryology,Xi'an Medical University,Xi'an,Shaanxi 710021,China)

机构地区：[1]西安医学院基础与转化医学研究所陕西省缺血性心血管疾病重点实验室,陕西省西安市710021 [2]空军军医大学口腔医院麻醉科,陕西省西安市710032 [3]西安医学院组织学与胚胎学教研室,陕西省西安市710021

出　　处：《中国动脉硬化杂志》2021年第10期903-907,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81900399、81400328、81773795);陕西省教育厅重点科研计划项目(19JS060);陕西省中医药局科技计划项目(2019-ZZ-JC034);西安医学院博士科研启动经费(2018DOC12)。

摘　　要：分泌卷曲相关蛋白4(SFRP4)是Wnt信号通路的抑制因子,在人类个体发育过程中发挥重要作用。同时,SFRP4基因表达和蛋白分泌异常导致机体发生病理变化。本文介绍了SFRP4基因和蛋白的结构特征、组织分布以及胚胎发育过程中的表达变化。临床研究发现,糖尿病患者血清中SFRP4蛋白水平显著升高,其与胰岛素分泌呈负相关。作为Wnt信号通路的抑制因子,SFRP4在调控脂肪形成、糖代谢以及胰岛素抵抗等生理和病理生理过程中扮演着重要角色。近年来,SFRP4在肥胖、脂质代谢紊乱以及糖尿病发生中的病理作用引起了广泛关注,并取得了重要进展。对其进一步系统深入的研究,不仅可以揭示肥胖、脂质代谢紊乱和糖尿病发生的新机制,也有望发现临床药物治疗新靶点。Secreted frizzled related protein 4(SFRP4)is an antagonistic inhibitor of Wnt signaling and plays an important role in human development.Abnormal gene expression and protein secretion of SFRP4 result in the pathological changes.This review introduced the structural characteristics,tissue distribution and expression pattern of SFRP4 during embryonic development.As an inhibitor of Wnts signaling,SFRP4 plays a key role in regulating adipogenesis.In clinic,the level of SFRP4 protein in the serum of diabetic patients was abnormally increased,which was negatively correlated with insulin secretion,indicating that SFRP4 plays an important role in the process of glucose metabolism and insulin resistance.In recent years,SFRP4 has attracted extensive attention in the research of obesity and lipid metabolism.Systematic research on SFRP4 can not only provide information related to diseases,but also serve as a novel drug and treatment target.

关 键 词：分泌卷曲相关蛋白4 脂质形成 脂肪细胞分化 糖尿病 肥胖 

分 类 号：R5[医药卫生—内科学] R3[医药卫生—临床医学]