间硝基苯乙酮在微通道反应器中的连续流合成研究  

Continuous flow synthesis of m-nitroacetophenone in a microchannel reactor

作　　者：王晓东 刘健 蒋涛[1,2] 李英利 李艳秋[1,2] 乔奇伟 WANG Xiao-dong;LIU Jian;JIANG Tao;LI Ying-li;LI Yan-qiu;QIAO Qi-wei(Changzhou Vocational Institute of Engineering,Changzhou 213164,China;Changzhou Key Laboratory of Microfluidic Chip Technology and Device,Changzhou 213164,China)

机构地区：[1]常州工程职业技术学院,江苏常州213164 [2]常州市微流控芯片技术及装备重点实验室,江苏常州213164

出　　处：《现代化工》2021年第9期165-167,共3页Modern Chemical Industry

基　　金：常州市微流控芯片技术及装备重点实验室资助项目(CM20183001);江苏省“六大人才高峰”高层次人才资助项目(GDZB-078)。

摘　　要：在碳化硅材质微通道反应器中,以苯乙酮为原料、硝酸为硝化剂、浓硫酸为溶剂合成间硝基苯乙酮。考察反应物料摩尔比、混酸摩尔比、反应温度、反应停留时间等工艺参数对反应的影响并对其进行优化。结果表明,当n(苯乙酮)∶n(硝酸)∶n(硫酸)=1∶1.5∶2、反应体系温度为10℃、停留时间为110 s时,反应效果最佳。该工艺充分利用了微通道反应器优良的传质传热特点,有利于对反应的精确控制和降低能耗,并减少副反应的发生。Using acetophenone as raw material,nitric acid as nitrating agent,and concentrated sulfuric acid as solvent,m-nitroacetophenone is synthesized via continuous flow process in a silicon carbide microchannel reactor. The influences of process conditions such as the molar ratio of reactants,the molar ratio of mixed acids,reaction temperature,and residence time on the reaction are investigated,and the conditions are optimized. The best reaction effect can be achieved when n( acetophenone) ∶n( nitric acid) ∶n( sulfuric acid) = 1 ∶1. 5 ∶2,the temperature of the reaction system is at10℃,and the residence time is 110 s.This process makes full use of the excellent mass and heat transfer characteristics of the microchannel reactor,which is conducive to the precise control of the reaction,reducing energy consumption,and reducing the occurrence of side reactions.

关 键 词：苯乙酮 硝化反应 微通道反应器 连续流工艺 尺度效应 

分 类 号：TQ203.9[化学工程—有机化工]