不同剂量戊酸雌二醇与子宫球囊支架预防宫腔粘连分离术后再粘连的临床应用效果  

Clinical Effect of Different Doses of Estradiol Valerate and Uterine Balloon Stents on Prevention of Readhesion after Separation of Intrauterine Adhesions

作　　者：张颂华[1] 王晓平[1] 徐金花[1] 陈家茹 罗广华 ZHANG Songhua;WANG Xiaoping;XU Jinhua;CHEN Jiaru;LUO Guanghua(Huangjiang Hospital of Dongguan,Dongguan 523750,China;不详)

机构地区：[1]东莞市黄江医院,广东东莞523750

出　　处：《中外医学研究》2021年第25期19-22,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析不同剂量戊酸雌二醇与子宫球囊支架预防宫腔粘连分离术后再粘连的临床应用效果。方法:选取2018年2月-2020年11月本院实施宫腔粘连分离术的62例患者作为观察对象,按照用药剂量的不同分为小剂量组(30例)和大剂量组(32例)。所有患者均在宫腔粘连分离术后放置子宫球囊支架,小、大剂量组分别采用2、6 mg/d戊酸雌二醇进行治疗。对比两组总有效率、不良反应发生率、宫腔再粘连发生情况及凝血功能指标。结果:大剂量组治疗总有效率为96.88%,显著高于小剂量组的76.67%(P<0.05),大剂量组不良反应发生率为15.63%,小剂量组为10.00%,差异无统计学意义(P>0.05);大剂量组宫腔再粘连率为3.13%,显著低于小剂量组的20.00%(P<0.05);两组治疗前后凝血功能指标比较差异无统计学意义(P>0.05)。结论:采用大剂量的戊酸雌二醇与子宫球囊支架预防宫腔粘连分离术后再粘连效果良好,不良反应少,凝血功能影响低,具有较高的临床应用价值。Objective:To analyze the clinical effect of different doses of Estradiol Valerate combined with uterine balloon stents in the prevention of readhesion after separation of intrauterine adhesions.Method:A total of 62 patients in our hospital from February 2018 to November 2020 who underwent intrauterine adhesion separation were selected as observation objects.They were divided into low dose group (30 cases) and high dose group (32 cases).All patients were treated with uterine balloon stents after intrauterine adhesion separation,and the low dose group and large dose group were treated with 2,6 mg/d Estradiol Valerate,respectively.The total effective rate,the incidence of adverse reactions,the occurrence of intrauterine readhesion and coagulation function indexes were compared between the two groups.Result:The total effective rate was 96.88% in high dose group,which was significantly higher than 76.67% in low dose group (P<0.05);the incidence of adverse reactions in high dose group was 15.63%,low dose group was 10.00%,there was no statistical difference (P>0.05);the rate of intrauterine readhesion in high dose group was 3.13%,which was significantly lower than 20.00% in low dose group (P<0.05);there was no significant difference in coagulation function indexes before and after treatment between the two groups (P>0.05).Conclusion:Using large dose of Estradiol Valerate and uterine balloon stents to prevent readhesion after separation of intrauterine adhesions has a good therapeutic effect,and its adverse reaction is small,and will not cause significant effect on coagulation function,it has a high application value in clinic.

关 键 词：不同剂量 戊酸雌二醇 子宫球囊支架 宫腔粘连 术后再粘连 

分 类 号：R713.4[医药卫生—妇产科学]