IL-8在慢性鼻窦炎中的表达及作用  

The expression and role of interleukin-8 in chronic rhinosinusitis

作　　者：王耀洁 李春花 刘红兵[1] WANG Yaojie;LI Chunhua;LIU Hongbing

机构地区：[1]南昌大学第二附属医院耳鼻咽喉头颈外科,南昌330006

出　　处：《临床耳鼻咽喉头颈外科杂志》2021年第8期765-768,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：白细胞介素8(IL-8)是CXC趋化因子的一员,可由单核细胞、巨噬细胞和成纤维细胞等多种细胞释放。它在气道炎症中起重要作用,与哮喘、支气管扩张[1-2]等疾病都有着密切的联系。IL-8有个很重要的功能,就是趋化中性粒细胞,促进中性粒细胞的募集、抗菌功能和延长体外存活时间。除此之外,IL-8还具有参与血管生成、趋化嗜酸粒细胞及T淋巴细胞[3-5]等作用。Interleukin-8(IL-8) is an inflammatory factor secreted by multiple cells. It has a variety of biological effects such as trending inflammatory cells and promoting angiogenesis in the body. Currently, it is found to play an important role in promoting airway inflammation. Chronic rhinosinusitis is a chronic inflammatory disease of the nasal cavity and sinus mucosa. Under the stimulation of a variety of factors, the secretion of IL-8 in the nasal mucosa and nasal polyps of CRS patients could increase. Therefore, it can cause inflammation and mucosal damage by trending chemotaxis neutrophils and eosinophils.

关 键 词：白细胞介素8 鼻窦炎 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]