中山市献血人群HTLV感染筛查情况调查分析  

Investigation and Analysis of HTLV Screening Infection in Voluntary Blood Donors in Zhongshan

作　　者：邝永晴 孙爱农 廖艳婷 吴泳伦 KUANG Yong-qing;SUN Ai-nong;LIAO Yan-ting;WU Yong-lun(Zhongshan Blood Center,Guangdong Zhongshan 528400)

机构地区：[1]中山市中心血站,广东中山528400

出　　处：《深圳中西医结合杂志》2021年第15期34-36,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:了解中山地区无偿献血人群中人类T淋巴细胞白血病病毒(HTLV)的感染状况。方法:采用酶联免疫吸附试验(ELISA)对中山市2016年3月1日至2020年5月31日无偿献血者血液标本144263份进行HTLV抗体初筛,ELISA阳性标本送广州市血液中心进行化学发光法、蛋白印迹法(WB)和聚合酶链式反应(PCR)检测法,做进一步确诊。结果:本研究共筛查144263例献血样本,发现初筛阳性率为0.087%(125/144263),确诊阳性4例,阳性率为0.0028%(4/144263)。结论:中山市属于HTLV低流行地区,在保证血液安全的前提下,综合考虑血液安全和经济成本效益,降低HTLV经血传播风险,可考虑采用过滤器去除血液中的白细胞。Objective To characterize the infection status of Human T lymphocyte virus(HTLV)among voluntary blood donors in Zhongshan.Methods Enzyme linked immunosorbent assay(ELISA)was used to screen the blood donation samples from March 1st,2016 to May 31st,2020 in Zhongshan,the positive samples were sent to Guangzhou Blood Center for immunohistochemical method、Western blot(WB)and polymerase chain reaction(PCR)detection for further confirmation.Results A total of 144263 unpaid blood donation samples were screened.The positive rate of initial screening was 0.087%(125/144263),and 4 cases were confirmed positive,with the positive rate of 0.0028%(4/144263).Conclusion The blood donors in Zhongshan is HTLV low prevalence population.Comprehensive consideration of blood safety and economic cost-effectiveness,leukocyte-depleted blood components can be promoted to reduce the risk of HTLV transfusion.

关 键 词：人类T淋巴细胞白血病病毒 献血人群 血液筛查 中山市 

分 类 号：R373[医药卫生—病原生物学] R446.11[医药卫生—基础医学]