Spinophilin在神经系统疾病中的研究进展  

Research progress of spinophilin in nervous system diseases

作　　者：邢靖松 克甜甜 张琳 梁东 张桐 高尚锋 XING Jing-song;KE Tian-tian;ZHANG Lin;LIANG Dong;ZHANG Tong;GAO Shang-feng(Department of Neurosurgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002;Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, China)

机构地区：[1]徐州医科大学附属医院神经外科,江苏徐州221002 [2]徐州医科大学神经系统疾病研究所,江苏徐州221002

出　　处：《基础医学与临床》2021年第10期1507-1509,共3页Basic and Clinical Medicine

基　　金：国家自然科学基金面上项目(82072763);江苏省“六大人才高峰”高层次人才项目(2019-SWYY-092);江苏省高等学校大学生创新创业训练计划(201810313044Y)。

摘　　要：Spinophilin(SPN)最早作为蛋白磷酸酶PP1的结合蛋白从神经元树突棘中分离出来,故又名PPP1R9B。SPN不仅与PP1结合,而且与包括细胞骨架蛋白、黏附分子等30多个蛋白存在相互作用,参与突触可塑性、神经元迁移、胞内信号传导等生物学过程,并在神经退行性疾病、精神性疾病和神经肿瘤进展中发挥重要作用。因此,了解SPN在上述生理和病理过程中的作用及机制将有助于推进SPN基础研究与临床转化的进展。Spinophilin(SPN)was first isolated from the dendritic spines of neurons as a binding protein of protein phosphatase PP1,it is also known as PPP1R9B.SPN can not only bind to PP1,but also interacts with more than 30 proteins,including cytoskeleton proteins and adhesion molecules.SPN participates in biological processes such as synaptic plasticity,neuronal migration,intracellular signal transduction,and plays an important role in the development of neurodegenerative diseases,psychiatric disorders and neuronal tumors.Therefore,understanding the role and mechanism of SPN in the physiological and pathological processes may support is helpful to advance the basic research and clinical transformation.

关 键 词：SPINOPHILIN 帕金森病 抑郁症 胶质瘤 

分 类 号：R651[医药卫生—外科学]