以人血清白蛋白为载体的Ru(Ⅲ)和全反式维甲酸共运输纳米药物的构建及抗肿瘤转移作用  

Using Human Serum Albumin Nanoparticle as Carrier for co-Delivery of Ru(Ⅲ)Complex and All-trans-retinoic Acid and Its Application for Anti-Metastasis Therapy

作　　者：丁鑫 师红东 刘扬中[1] DING Xin;SHI Hongdong;LIU Yangzhong(Department of Chemistry,University of Science and Technology of China,Hefei 230026,China;College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen 518060,China)

机构地区：[1]中国科学技术大学化学与材料科学学院化学系,合肥230026 [2]深圳大学化学与环境工程学院,深圳518060

出　　处：《高等学校化学学报》2021年第10期3040-3046,共7页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21907069)资助.

摘　　要：设计合成了一种以人血清蛋白纳米颗粒(HSANP)为载体,共运输Ru(Ⅲ)配合物和全反式维甲酸(ATRA)的纳米药物Ru-ATRA-HSANP,用于抗肿瘤转移治疗.该药物在水中和生理条件下表现出优异的稳定性,可以被细胞有效摄取,具有较弱的细胞毒性,但表现出优异的抗肿瘤转移效果.因此,构建了一种稳定、低毒性的抗肿瘤转移纳米药物,有望用于抗肿瘤转移治疗.Cancer is one of the main diseases threatening human life and health.Approximately 9.96 million people die from cancer each year in the world.More than 90%of cancer deaths are caused by metastasis.Therefore,the development of effective anti-metastasis drugs is of great significance for cancer treatment.In this paper,a nano-drug system based on human serum albumin(HSANP)was designed and synthesized to co-deliver Ru(Ⅲ)complex and all-trans-retinoic acid(ATRA)for anti-metastatic therapy.Ru-ATRA-HSANP shows excellent stability under water and physiological conditions and could be effectively internalized by cells.It has weak cytotoxicity,but exhibits excellent anti-metastatic effects.In conclusion,an anti-metastatic nanomedicine with good stability and low-toxicity have been constructed,which could be used for anti-metastasis therapy.

关 键 词：抗肿瘤转移 Ru(Ⅲ)配合物 全反式维甲酸 共运输 纳米药物 

分 类 号：O614[理学—无机化学]