基于激光介导富集的表面增强拉曼分析  

Laser-mediated Enrichment Based Surface Enhanced Raman Analysis

作　　者：唐文涛 李圣凯 王昚 陈龙[2] 陈卓 TANG Wentao;LI Shengkai;WANG Shen;CHEN Long;CHEN Zhuo(Molecular Science and Biomedicine Laboratory(MBL),State Key Laboratory of Chemo/Bio-Sensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China;Faculty of Science and Technology,University of Macao,Macao 999078,China)

机构地区：[1]湖南大学化学化工学院,化学生物传感与计量学国家重点实验室,分子科学与生物医学实验室,长沙410082 [2]澳门大学科技学院,澳门999078

出　　处：《高等学校化学学报》2021年第10期3054-3061,共8页Chemical Journal of Chinese Universities

基　　金：湖南省科技创新计划项目(批准号:2020RC4017);澳门科技发展基金(批准号:196/2017/A3)资助.

摘　　要：基于具有优异表面增强拉曼散射(SERS)性能的石墨烯隔离的金纳米晶(GIAN)能够在水-有机相界面自组装,待测物分子在有机相中的分配系数较大以及GIAN能够通过π⁃π相互作用与待测物分子结合的优势,构建了激光介导的待测物分子的高效富集策略,进而实现了9,10-双苯乙炔基蒽(BPEA)分子的痕量SERS分析.所构建的新型待测物分子高效富集策略在一定程度上避免了因“咖啡环效应”带来的信号波动,有望为复杂体系中痕量待测物的SERS分析提供可靠的平台.Surface enhanced Raman scattering(SERS)technique has extensive application prospects in biochemical analysis and environmental monitoring field owing to its high sensitivity,low background inter-ference,superior anti-photobleaching and anti-photocarbonization capabilities,as well as ability to reflect the inherent molecular fingerprint information of the analyte.Non-target analytes are competitively adsorbed on the surface of the SERS substrate,making the analysis of trace analytes in complex systems extremely challenging.Based on the self-assemble of the graphene-isolated Au nanocrystal(GIAN)with excellent SERS performance at H2O-Organic phase interface,the large partition coefficient of the analyte in organic phase,and GIAN can combine with the analyte viaπ-πinteraction,a laser-mediated highly-efficient analyte enrichment strategy is proposed and trace SERS analysis of 9,10-bis(phenylethynyl)anthracene(BPEA)molecules is eventually realized in this work.The proposed novel analyte enrichment strategy avoids the signal fluctuation caused by the“coffee ring effect”to a certain extent and is expected to provide a reliable platform for SERS analysis of trace analytes in complex systems.

关 键 词：激光介导的富集 表面增强拉曼散射 两相界面 石墨烯隔离的金纳米晶 自组装 

分 类 号：O657.37[理学—分析化学]