用于磁性靶向治疗肺纤维化的聚多巴胺包覆的Fe_(3)O_(4)/甲强龙/环磷酰胺复合超粒子  

Polydopamine-coated Fe_(3)O_(4)/methylprednisolone/cyclophosphamide Superparticles for the Magnetic Targeting Treatment of Pulmonary Fibrosis

作　　者：孙启睿 赵楠 刘树威 辛华[2] 张皓[1] 张乐宁[2] SUN Qirui;ZHAO Nan;LIU Shuwei;XIN Hua;ZHANG Hao;ZHANG Lening(College of Chemistry,Jilin University,Changchun 130012;Department of Thoracic Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,China)

机构地区：[1]吉林大学化学学院,长春130012 [2]吉林大学中日联谊医院胸外科,长春130033

出　　处：《高等学校化学学报》2021年第10期3225-3232,共8页Chemical Journal of Chinese Universities

基　　金：吉林省科技发展计划项目(批准号:20190701027GH);吉林省教育厅科学技术项目(批准号:JJKH20211199KJ);吉林省发展改革委产业技术研究与开发项目(批准号:2019C049-8)资助.

摘　　要：肺纤维化是一种致命性肺部疾病,目前临床常规的甲强龙(MPS)联合环磷酰胺(CTX)治疗方法存在明显的不良反应.基于降低药物毒副作用的目的,本文设计了一种聚多巴胺(PDA)包覆的Fe_(3)O_(4)纳米粒子/甲强龙/环磷酰胺复合超粒子(Fe_(3)O_(4)/MPS/CTX@PDA SPs),提出磁性靶向治疗肺纤维化的思路.从预制的油溶性Fe_(3)O_(4)纳米粒子出发,通过水包油微乳液模板法制备了Fe_(3)O_(4)超粒子(SPs),并在进一步包覆PDA壳层的过程中引入MPS和CTX,制备了Fe_(3)O_(4)/MPS/CTX@PDA SPs,考察了Fe_(3)O_(4)/MPS/CTX@PDA SPs的稳定性、磁性、对MPS和CTX的负载及释放,分析了其生物毒性,并建立动物模型验证了其磁性靶向功能.Pulmonary fibrosis is a serious fatal disease and it exists clinical adverse effects for the convention⁃al combined treatment using methylprednisolone(MPS)and cyclophosphamide(CTX).In this work,polydopa⁃mine(PDA)-coated Fe_(3)O_(4)/MPS/CTX superparticles(Fe_(3)O_(4)/MPS/CTX@PDA SPs)were prepared to reduce the adverse effects of drugs,which provide a magnetic targeting strategy for the therapy of pulmonary fibrosis.In the experiment,Fe_(3)O_(4) SPs were foremost prepared from Fe_(3)O_(4) nanoparticles using oil-in-water droplets as the templates,and followed by coating PDA shell in the presence of MPS and CTX to produce Fe_(3)O_(4)/MPS/CTX@PDA SPs.Systematically characterizations proved the successful preparation of Fe_(3)O_(4)/MPS/CTX@PDA SPs,and revealed the stability,magnetism,drug loading and release.The cytotoxicity was further discussed in vitro,and an animal model was built to confirm the magnetic targeting of Fe_(3)O_(4)/MPS/CTX@PDA SPs in vivo.

关 键 词：聚多巴胺 Fe_(3)O_(4)纳米粒子 超粒子 肺纤维化 磁性靶向 

分 类 号：O631[理学—高分子化学]