纳米硅酸镁锂-壳聚糖-海藻酸钠复合支架材料的制备与性能  

Preparation and Properties of Nano Lithium Magnesium Silicate-chitosan-sodium Alginate Composite Scaffold Materials

作　　者：王明霞 刘志辉[2] 朱镇 李凌锋 王博蔚[1] WANG Mingxia;LIU Zhihui;ZHU Zhen;LI Lingfeng;WANG Bowei(The Second Hospital of Jilin University,Changchun 130021,China;Hospital of Stomatology,Jilin University,Changchun 130021,China;Zhenjiang Stomatological Hospital,Zhenjiang 212001,China)

机构地区：[1]吉林大学第二医院,长春130021 [2]吉林大学口腔医院,长春130021 [3]镇江市口腔医院,镇江212001

出　　处：《高等学校化学学报》2021年第10期3240-3246,共7页Chemical Journal of Chinese Universities

基　　金：吉林省科技发展计划项目(批准号:20180201056YY,20190304032YY,20200708127YY,20200301008RQ);吉林大学研究生创新计划项目(批准号:101832020CX310);镇江市科技发展计划项目(批准号:SH2019040)资助.

摘　　要：利用真空冷冻干燥技术,将不同质量的纳米硅酸镁锂(nLMS)与壳聚糖(CA)和海藻酸钠(SA)混合,制备了纳米硅酸镁锂-壳聚糖-海藻酸钠(nLMS-CS-SA)复合支架材料.研究了不同质量分数(1%,2%,3%,4%)的nLMS对nLMS-CS-SA复合支架材料的外形、微观形貌、溶胀率、孔隙率、体外降解性能和生物相容性的影响,以确定nLMS-CS-SA复合支架材料中最佳nLMS含量.研究结果显示,nLMS-CS-SA复合支架材料是具备形态可塑性的多孔状固体,各组材料纵断面呈片层状,其结构疏松且内部孔隙具有高度连通性;随着nLMS含量的增加,nLMS-CS-SA复合支架材料的孔隙率呈现先降后升的趋势;当nLMS的质量分数为3%时,其溶胀比最小,体外降解速率最慢;nLMS的添加降低了nLMS-CS-SA复合支架材料的毒性.因此,nLMS在nLMS-CS-SA复合支架材料中的最佳含量为3%.Using vacuum freeze-drying technology,composite scaffolds were fabricated by mixing different mass fractions of nano-lithium magnesium silicate(nLMS)with chitosan and sodium alginate.Results showed that the composite scaffolds were porous solids possessing morphological plasticity,the longitudinal section of the composite scaffold was lamellar,the structure was loose and the internal pores were highly connected.With the increase of nLMS content,the porosity of the composite scaffold decreased and then increased.When the mass fraction of nLMS solution was 3%,both the swelling ratio and the degradation rate of the composite scaffold were the lowest.Besides,the addition of nLMS reduced the toxicity of the composite scaffold.The optimal mass fraction of nLMS solution to prepare the composite scaffold is 3%.

关 键 词：骨组织工程 支架 壳聚糖 海藻酸钠 硅酸镁锂 

分 类 号：O636[理学—高分子化学]