成年住院病人感染耐碳青霉烯类肺炎克雷伯菌的危险因素研究  

Study on the risk factors of carbapenem-resistant Klebsiella pneumoniae infection in adult inpatients

作　　者：朱敬蕊[1] 段缓[1] 崔琢[1] 张向君[1] ZHU Jing-rui;DUAN Huan;CUI Zhuo;ZHANG Xiang-jun(Department of Nosocomial Infection Management,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院医院感染管理科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2021年第9期1201-1203,1207,共4页Journal of Bengbu Medical College

基　　金：安徽省高校人文社会科学研究项目(SK2019A0207)。

摘　　要：目的:分析医院成年住院病人耐碳青霉烯类肺炎克雷伯菌(CRKP)感染的影响因素。方法:收集医院感染肺炎克雷伯菌的成年住院病人临床资料,根据肺炎克雷伯菌对碳青霉烯类抗生素是否耐药,分为CRKP组和碳青霉烯类敏感肺炎克雷伯菌组,分析CRKP感染的影响因素。结果:单因素分析显示,是否入住重症监护室、使用碳青霉烯类抗菌药物、使用呼吸机和使用导尿管在2组间差异均有统计学意义(P<0.01)。多因素分析显示,入住重症监护室和使用呼吸机均为CRKP感染的独立危险因素(P<0.01)。结论:加强重症监护室的耐药监测,开展定植筛查,规范使用抗菌药物,重视医务人员无菌操作和手卫生,严格落实消毒隔离措施有助于控制CRKP的传播。Objective:To analyze the influencing factors of carbapenem-resistant Klebsiella pneumoniae(CRKP)infection in adult inpatients.Methods:The clinical data of adult inpatients infected with Klebsiella pneumoniae were collected.According to whether Klebsiella pneumoniae was resistant to carbapenem antibiotics,the patients were divided into the CRKP group and carbapene sensitive Klebsiella pneumoniae(CSKP)group.The influencing factors of CRKP infection were analyzed.Results:The results of univariate analysis showed that the differences of CRKP infection in the admission to intensive care unit,use of carbapenem antibacterial drugs,use of ventilator and use of catheter were statistically significant(P<0.01).The results of multivariate analysis showed that the admission to intensive care unit and use of ventilator were the independent risk factors of CRKP infection(P<0.01).Conclusions:It is helpful to control the spread of CRKP by strengthening the monitoring of drug resistance in intensive care units,carrying out screening for colonization,standardizing the use of antibiotics,paying attention to aseptic operation and hand hygiene of medical staff,and strictly implementing disinfection and isolation measures.

关 键 词：医院感染 肺炎克雷伯菌 碳青霉烯酶 耐药 

分 类 号：R197.3[医药卫生—卫生事业管理]