幽门螺杆菌感染对2型糖尿病病人代谢水平的影响  

Effect of Helicobacter pylori infection on metabolic levels in patients with type 2 diabetes mellitus

作　　者：金齐力[1] 韩玮玮[1] 程霞[1] 杨玉萍[1] JIN Qi-li;HAN Wei-wei;CHENG Xia;YANG Yu-ping(Department of Clinical Laboratory,The Second Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233040,China)

机构地区：[1]蚌埠医学院第二附属医院检验科,安徽蚌埠233040

出　　处：《蚌埠医学院学报》2021年第9期1252-1254,共3页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究重点资助项目(KJ2017A229)。

摘　　要：目的:探讨幽门螺杆菌(Helicobacter pylori,HP)感染对2型糖尿病(T2DM)病人代谢水平的影响。方法:共纳入175例T2DM病人,按HP感染情况分为HP感染组和HP未感染组。收集或检测每位病人的年龄、性别、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白-a(LP-a)、空腹血糖(Glu)、糖化血红蛋白(HbA1c)等。通过比较2组间的检测结果分析HP感染对T2DM病人代谢水平的影响。结果:175例T2DM病人中,HP感染91例(52%),HP未感染84例(48%),T2DM合并HP感染组血清LP-a和HbA1c(%)水平均高于HP未感染组(P<0.01);T2DM病人HbA1c(%)>8的比例,HP感染者高于HP未感染者,差异有统计学意义(P<0.01);2组间其他指标差异均无统计学意义(P>0.05)。结论:HP感染影响T2DM病人的血糖血脂代谢,可能参与代谢异常相关性疾病的发生和发展。Objective:To investigate the effect of Helicobacter pylori(HP)infection on metabolic levels in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 175 patients with T2DM were included in this study.These patients were divided into two groups as HP infection-positive or-negative.For each patient,the following data were collected or measured:age,gender and laboratory parameters including total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),lipoprotein-a(LP-a),fasting blood glucose(Glu)and glycosylated hemoglobin(HbA1c).The influence of HP infection on the metabolic levels of T2DM patients was analyzed by comparing the results between the two groups.Results:Among 175 T2DM patients,91 patients(52%)were HP positive and 84 patients(48%)were HP infection-negative.T2DM patients infected by HP showed significantly increased Lp-a and higher HbA1c than non-infected patients(P<0.01).Additionally,65.9%of the patients with HbA1c>8%were found to be HP positive,55.6%of the patients with HbA1c≤8%were HP positive.The levels of other parameters were not significantly different between two groups(P>0.05).Conclusions:HP infection affects blood glucose and lipid metabolism in patients with T2DM,which may be involved in the occurrence and development of metabolic disorder associated diseases.

关 键 词：2型糖尿病 幽门螺杆菌 代谢水平 

分 类 号：R587.1[医药卫生—内分泌]