2型糖尿病患者内脏脂肪面积与肥胖及糖脂代谢指标的相关性  

The Correlation between Visceral Fat Area in Patients with Type 2 Diabetes and Obesity and Glycolipid Metabolism

作　　者：杨璐[1] 施文军 赵玲[1] 杜士刚 陈珮琪 柯亭羽[1] YANG Lu;SHI Wen-jun;ZHAO Ling;DU Shi-gang;CHEN Pei-qi;KE Ting-yu(Dept.of Endocrinology,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院内分泌科,云南昆明650101

出　　处：《昆明医科大学学报》2021年第9期65-70,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81260229);云南省科技厅-昆明医科大学应用基础联合专项基金资助项目[2018FE001(-228)];云南省高层次卫生计生技术人才培养基金资助项目(L-2019014 H-2017043);昆明医科大学第二附属医院人才培养计划基金资助项目(RCPYXM2017-3-16);云南省卫生科技计划基金资助项目(2018NS0293);昆明医科大学研究生创新基金资助项目(2021S061)。

摘　　要：目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者不同程度内脏脂肪面积与肥胖相关指标及糖脂代谢指标的相关性。方法选取2017年10月至2018年9月就诊于昆明医科大学第二附属医院的682例T2DM患者纳入研究,通过内脏脂肪检测仪(DUALSCAN HDS-2000)检测内脏脂肪面积(visceral fat area,VFA)并按VFA 0~50 cm^(2)、50~100 cm^(2)、100~150 cm^(2)、≥150 cm^(2)分为A、B、C、D 4组。比较4组腰围、BMI、腹部皮下脂肪面积、胰岛素(INS)及C-肽(C-P)释放试验、尿酸(UA)、血脂、HCY、胱抑素C(Cysc)的差异并分析相关性,以探讨2型糖尿病患者VFA与各检测指标的关系的相关性。结果内脏脂肪面积与腰围、BMI、腹部皮下脂肪面积呈正相关(r>0,P<0.05)。A、B、C、D 4组INS(0 h、1 h、2 h)、C-P(0 h、1 h、2 h)、UA水平依次递增(P<0.05),VFA与INS(0 h、1 h、2 h、3 h),C-P(0 h、1 h)、TG、APOE、UA、CYSC均呈正相关(r>0,P<0.05)。结论2型糖尿病患者VFA与肥胖、胰岛素抵抗、甘油三酯、尿酸、CYSC呈正相关。Objective To explore the relationship between the different degrees of visceral fat area and obesity indexes and glycolipid metabolism indexes in type 2 diabetes patients.Methods From October 2017 to September 2018,682 T2DM patients admitted to the Endocrinology Department of the 2nd Affiliated Hospital of Kunming Medical University were included in this study.The visceral fat area(VFA)was measured by the visceral fat detector(DUALSCAN HDS-2000)and divided into group A,B,C and D according to VFA 0~50 cm^(2),50~100 cm^(2),100~150 cm^(2) and≥150 cm^(2).The differences of waist circumference,BMI,abdominal subcutaneous fat area,insulin(INS)and C-peptide(C-P)release test,uric acid(UA),blood lipid,HCY,Cystatin C(Cysc)in the four groups were compared and the correlation was analyzed.Results There was a positive correlation between the visceral fat area and obesity-related indicators(r>,P<0.05).VFA was positively correlated with INS(0 h,1 h,2 h,3 h),C-P(0 h,1 h),TG,APOE,UA,CYSC(r>0,P<0.05).Conclusion VFA is positively correlated with obesity,insulin resistance,triglyceride,uric acid and CYSC in patients with type 2 diabetes.The greater the VFA,the more severe the degree of obesity and insulin resistance,and the higher the blood uric acid and triglyceride.

关 键 词：2型糖尿病 内脏脂肪面积 脂质代谢 糖代谢 肥胖 

分 类 号：R587.1[医药卫生—内分泌]