NLRP3炎性体在高血压及其靶器官损伤中的研究进展  

NLRP3 Inflammasome in Hypertension and Its Target Organ Damage

作　　者：闫宣池 郭雨桐 刘越[1] 李利君 刘文秀[1] YAN Xuanchi;GUO Yutong;LIU Yue;LI Lijun;LIU Wenxiu(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2021年第9期829-833,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81700318);哈尔滨医科大学大学生创新创业训练计划(201910226157)。

摘　　要：高血压是影响全球健康的重要疾病之一,可导致心脏、脑、肾脏和血管等靶器官损伤。近年来,对于NLRP3炎性体在高血压及其靶器官损伤中的作用及机制进行了研究,发现其与高血压及其靶器官损伤密切相关。如高血压患者NLRP3炎性体的活化,与高血压所致心肌肥厚和纤维化、血管内皮损伤和平滑肌增殖、肾脏炎症和纤维化以及高血压脑病相关。因此,现就NLRP3炎性体在高血压及其靶器官损伤中的研究进展进行综述。Hypertension is one of the most important diseases affecting global health,which can cause damage to target organs such as heart,brain,kidney and blood vessels.In recent years,the role and mechanism of NLRP3 inflammasome in hypertension and its target organ injury have been studied,and it has been found that it is closely related to the hypertension and its target organ injury.For example,NLRP3 inflammasome activation in patients with hypertension is related to hypertension-induced myocardial hypertrophy and fibrosis,vascular endothelial injury and smooth muscle proliferation,renal inflammation and fibrosis and hypertensive encephalopathy.Therefore,in this paper,we review the research progress of NLRP3 inflammasome in hypertension and its target organ damage.

关 键 词：NLRP3炎性体 高血压 靶器官损伤 

分 类 号：R54[医药卫生—心血管疾病]