The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution  

作　　者：Xue Han Xi Huang Xing Wang Deng 

机构地区：[1]State Key Laboratory of Protein and Plant Gene Research,School of Advanced Agricultural Sciences,Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China [2]Peking University-Southern University of Science and Technology Institute of Plant and Food Science,Department of Biology,Southern University of Science and Technology,Shenzhen 518055,China [3]State Key Laboratory of Cellular Stress Biology,School of Life Sciences,Xiamen University,Xiamen 361102,China

出　　处：《Plant Communications》2020年第3期85-97,共13页植物通讯（英文）

基　　金：supported by grants from National Key R&D Program of China(2017YFA0503800);National Natural Science Foundation of China(31330048,31621001);Peking-Tsinghua Center for Life Sciences;Peking University;Southern University of Science and Technology;Xiamen University.

摘　　要：Green plants on the earth have evolved intricate mechanisms to acclimatize to and utilize sunlight.In Arabidopsis,light signals are perceived by photoreceptors and transmitted through divergent but overlapping signaling networks to modulate plant photomorphogenic development.COP1(CONSTITUTIVE PHOTOMORPHOGENIC 1)was first cloned as a central repressor of photomorphogenesis in higher plants and has been extensively studied for over 30 years.It acts as a RING E3 ubiquitin ligase downstream of multiple photoreceptors to target key light-signaling regulators for degradation,primarily as part of large protein complexes.The mammalian counterpart of COP1 is a pluripotent regulator of tumorigenesis and metabolism.A great deal of information on COP1 has been derived from whole-genome sequencing and functional studies in lower green plants,which enables us to illustrate its evolutionary history.Here,we reviewthe current understanding about COP1,with a focus on the conservation and functional diversification of COP1 and its signaling partners in different taxonomic clades.

关 键 词：COP1 E3 ubiquitin ligase PHOTOMORPHOGENESIS GRAVITROPISM light protection EVOLUTION 

分 类 号：Q94[生物学—植物学]