循环miRs在2型糖尿病中的研究进展  

Research progress of circulating miRNA in type 2 diabetes mellitus

作　　者：谢涛 张婷[1] 范茗华 罗晓婷[2] XIE Tao;ZHANG Ting;FAN Ming-hua;LUO Xiao-ting(Gannan Medical University;Department of Biochemistry and Molecular Biology,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院 [2]赣南医学院生物化学与分子生物学教研室,江西赣州341000

出　　处：《赣南医学院学报》2021年第9期892-899,共8页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(81660566);江西省教育厅项目(GJJ180825);心脑血管疾病防治教育部重点实验室开放课题(XN201907);国家级大学生创新创业项目(201910413007);赣南医学院研究生科技创新项目(YC2020-X026)。

摘　　要：2型糖尿病(Type 2 diabetes mellitus,T2DM)是由复杂的遗传和环境共同作用的一种内分泌代谢性疾病,其发病率和患病率在全球范围内以惊人的速度增加,并且T2DM尚无根治方法,因此寻找高度稳定性和可重复性的生物标志物逐渐成为T2DM研究的重点。微小核糖核酸(miRs/miRNA)是一类普遍存在的非编码单链RNA,通常在转录后抑制信使核糖核酸(Messenger RNA,mRNA)分子的翻译。其中人体血循环中存在大量稳定的miRNA,称为循环微小核糖核酸(Circulating miRNA)。循环miRNA表达异常可能与T2DM的发生、发展以及发病机制密切相关,可能为T2DM潜在的生物标志物。Type 2 diabetes mellitus is a metabolic disease with complex genetic and environmental roles.Its incidence rate and prevalence rate increase at an alarming rate worldwide,and T2DM has no radical cure.Therefore,finding highly stable and reproducible biomarkers has become the focus of T2DM research.miRNA is a kind of non-coding single stranded RNA,which usually inhibits the translation of messenger RNA(mRNA)after transcription.There are a large number of highly stable and abundant miRNA in human blood circulation,which are called circulating miRNA.The abnormal expression of circulating miRNA may be closely related to the occurrence,development and pathogenesis of T2DM,and become a potential biomarker of T2DM.

关 键 词：2型糖尿病 循环微小核糖核酸 生物标志物 

分 类 号：R181.13[医药卫生—流行病学]