采用ALDEN标准判别1例中毒性表皮坏死松解症病例的致敏药物与分析  

Identification of Sensitizing Drugs in a Case of Toxic Epidermal Necrolysis by ALDEN Standard

作　　者：张颖佩[1] 郑香宜 吴建华[1] Zhang Yingpei;Zheng Xiangyi;Wu Jianhua(Department of Pharmacy,Zhongnan Hospital of Wuhan University,Wuhan 430070,China)

机构地区：[1]武汉大学中南医院药学部,武汉430070

出　　处：《药物流行病学杂志》2021年第9期626-630,共5页Chinese Journal of Pharmacoepidemiology

摘　　要：本文报道1例脑出血术后患者出现中毒性表皮坏死松解症(toxic epidermal necrolysis, TEN)并死亡的案例,并引入表皮坏死松解症药物因果关系推算法(ALDEN)标准,对可能引发TEN药物相关性大小进行评价。根据ALDEN标准,临床药师从反应间隔时间、药物存在情况、激发试验、停药试验、潜在相关性和其他影响因素这6个方面评估患者所用药物导致TEN的可能性大小,从而筛选出最可能的致敏药物为莫西沙星。ALDEN标准作为一种针对TEN的特异性药品不良反应判断标准,值得被推广。This article records a case of toxic epidermal necrolysis(TEN) and death after cerebral hemorrhage, and introduces the Algorithm of Drug Causality for Epidermal Necrolysis(ALDEN) standards to evaluate the relevance of drugs that may trigger TEN. According to the ALDEN standard, the clinical pharmacist evaluates the likelihood of TEN caused by the drug used by the patient from the six aspects of response interval, drug presence, provocation test, drug withdrawal test, potential correlation and other influencing factors, so as to select the most possible allergenic drug, which seems to be moxifloxacin. As a judging standard for specific adverse drug reactions of TEN, the ALDEN standard is worthy of being promoted.

关 键 词：莫西沙星 中毒性表皮坏死松解症 死亡 ALDEN标准 药品不良反应 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]