Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications  

作　　者：Guoyin Chen Gang Wang Xinrong Tan Kai Hou Qingshuo Meng Peng Zhao Shun Wang Jiayi Zhang Zhan Zhou Tao Chen Yanhua Cheng D Benjamin S.Hsiao Elsa Reichmanis Meifang Zhu 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China [2]State Key Laboratory of Medical Neurobiology,MOE Frontiers Center for Brain Science,Institute of Brain Science,Department of Ophthalmology,Zhongshan Hospital,Fudan University,Shanghai 200032,China [3]Department of Chemistry,Stony Brook University,Stony Brook,NY 11794,USA [4]School of Chemical and Biomolecular Engineering,School of Chemistry and Biochemistry,School of Materials Science and Engineering,Georgia Institute of Technology,Atlanta,GA 30332,USA

出　　处：《National Science Review》2021年第9期83-94,共12页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(51733002 and 51803022);the National Key Research and Development Program of China(2016YFA0201702/2016YFA0201700);the Fundamental Research Funds for the Central Universities(2232018A3-01);the Program for Changjiang Scholars and Innovative Research Team in University(IRT 16R13);the Science and Technology Commission of Shanghai Municipality(16JC1400700);the Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-03-E00055);the China Postdoctoral Science Foundation(2018M631980);financial support from the Program for Professors of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning;the Young Elite Scientists Sponsorship Program by CAST;the Natural Science Foundation of Shanghai(19ZR1470900);support from the Fundamental Research Funds for the Central Universities;Graduate Student Innovation Fund of Donghua University(CUSF-DH-D-2020038)。

摘　　要：Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors,optogenetic stimulation and photomedicine due to their biocompatibility,(micro)structure control and tissue-like Young’s modulus.However,despite recent developments,large-scale fabrication with a continuous synthetic methodology,which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications,has yet to be achieved.In this study,we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters,and mechanical and optical propagation properties.Furthermore,this concept also exhibited versatility for various kinds of core-sheath functional fibers.The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility[core=poly(ethylene glycol diacrylate-co-acrylamide);sheath=Ca-alginate],optical transparency,refractive index and spinning solution viscosity.The resulting hydrogel optical fibers exhibited desirable low optical attenuation(0.18±0.01 d B cm^(-1) with 650 nm laser light),excellent biocompatibility and tissue-like Young’s modulus(<2.60 MPa).The optical waveguide hydrogel fibers were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation,confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications.

关 键 词：optical waveguide hydrogel fiber deep-tissue photothermal therapy optogenetic stimulatio 

分 类 号：R318.08[医药卫生—生物医学工程] TQ342[医药卫生—基础医学]