Input associativity underlies fear memory renewal  

作　　者：Wei-Guang Li Yan-Jiao Wu Xue Gu Hui-Ran Fan Qi Wang Jia-Jie Zhu Xin Yi Qin Wang Qin Jiang Ying Li- Ti-Fei Yuan Han Xu Jiangteng Lu Nan-Jie Xu Michael Xi Zhu Tian-Le Xu 

机构地区：[1]Center for Brain Science of Shanghai Children’s Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China [2]Department of Anatomy and Physiology,Shanghai Jiao Tong University School of Medicine,Shanghai 20025,China [3]JShanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 201108,China [4]Center for Neuroscience and Department of Neurology of the Second Affiliated Hospital,NHC and CAMS Key Laboratory of Medical Neurobiology,Zhejiang University School of Medicine,Hangzhou 310058,China [5]Department of Integrative Biology and Pharmacology,McGovern Medical School,University of Texas Health Science Center at Houston,Houston,TX 77030,USA [6]Shanghai Research Center for Brain Science and Brain-Inspired Intelligence,Shanghai 201210,China

出　　处：《National Science Review》2021年第9期116-131,共16页国家科学评论（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(31930050,81771214,31900701,32071023 and 81903583);the Science and Technology Commission of Shanghai Municipality(18JC1420302and 18QA1402500);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);SJTU Transmed Awards Research(2019015);the innovative research team of high-level local universities in Shanghai。

摘　　要：Synaptic associativity,a feature of Hebbian plasticity wherein coactivation of two inputs onto the same neuron produces synergistic actions on postsynaptic activity,is a primary cellular correlate of associative learning.However,whether and how synaptic associativity are implemented into context-dependent relapse of extinguished memory(i.e.fear renewal)is unknown.Here,using an auditory fear conditioning paradigm in mice,we show that fear renewal is determined by the associativity between convergent inputs from the auditory cortex(ACx)and ventral hippocampus(v HPC)onto the lateral amygdala(LA)that reactivate ensembles engaged during learning.Fear renewal enhances synaptic strengths of both ACx to LA and the previously unknown v HPC to LA monosynaptic inputs.While inactivating either of the afferents abolishes fear renewal,optogenetic activation of their input associativity in the LA recapitulates fear renewal.Thus,input associativity underlies fear memory renewal.

关 键 词：fear renewal memory ensembles input associativity long-term potentiation ventral hippocampus auditory cortex lateral amygdala 

分 类 号：R338.6[医药卫生—人体生理学]