沙库巴曲缬沙坦钠联合新活素治疗急性左心衰竭的疗效  

Clinical effect of sacubitril-valsartan combined with activin on acute left heart failure

作　　者：罗方林[1] 官素英 吴国祥[1] Luo Fanglin;Guan Suying;Wu Guoxiang(Department of Cardiology, the First Affiliated Hospital of Nanping, Fujian Medical University, Nanping 353000, China)

机构地区：[1]福建医科大学附属南平市第一医院心内一区,福建南平353000

出　　处：《临床荟萃》2021年第9期782-785,共4页Clinical Focus

摘　　要：目的探讨沙库巴曲缬沙坦钠联合新活素(冻干重组人脑利钠肽)治疗急性左心衰竭(ALHF)的疗效。方法选择本院2018年6月-2020年10月收诊的ALHF患者112例,随机数字表法分为试验组(56例,沙库巴曲缬沙坦钠联合新活素)与对照组(56例,沙库巴曲缬沙坦钠)2组,观察两组用药2周后的总有效率,分析其心率、血浆N末端B型利钠肽前体(NT-proBNP)、左心室射血分数(LVEF)水平,以及比较其丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平。结果实验组的总有效率高于对照组(92.86%vs 76.79%,P<0.05)。实验组用药后的心率、NT-proBNP、MDA低于对照组(P<0.05);而其LVEF、SOD、GSH-Px高于对照组(P<0.05)。结论沙库巴曲缬沙坦钠联合新活素方法有助于改善ALHF患者的心功能,减轻其氧化应激,稳定提升其临床疗效。Objective To investigate the clinical effect of sacubitril-valsartan combined with recombinant human brain natriuretic peptide for acute left heart failure(ALHF).Methods A total of 112 ALHF patients admitted to our hospital from June 2018 to October 2020 were by random number table method divided into experimental group(56 cases received sacubitril-valsartan combined with activin)and control group(56 cases received sacubitril-valsartan).After treatment,the total effective rate,heart rate,N-terminal pro-brain natriuretic peptide(NT-proBNP)and left ventricular ejection fraction(LVEF)were analyzed.Malondialdehyde(MDA),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were compared in two groups.Results The total effective rate in experimental group was higher than that of control group(92.86%vs 76.79%,P<0.05).After treatment,the heart rate,NT-proBNP and MDA were lower in experimental group than in control group(P<0.05),while LVEF,SOD and GSH-Px were higher than in control group(P<0.05).Conclusion Sacubitril-valsartan combined with activin can improve cardiac function for ALHF patients,reduce oxidative stress,and stably enhance clinical efficacy.

关 键 词：心力衰竭 氧化性应激 药物疗法 联合 

分 类 号：R541.61[医药卫生—心血管疾病]