TG/HDL-C、TyG、non-HDL-C预测中老年女性代谢综合征价值  

TG/HDL-C,TyG and non-HDL-C in predition of metabolic syndrome incidence in middle-aged and elderly women

作　　者：赵薇 罗兰 李珅 董莹莹 李欣宇 高政南 Zhao Wei;Luo Lan;Li Shen;Dong Yingying;Li Xinyu;Gao Zhengnan(Department of Endocrinology, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian 116033, China)

机构地区：[1]大连医科大学附属大连市中心医院内分泌科,辽宁大连116033

出　　处：《临床荟萃》2021年第9期790-794,共5页Clinical Focus

基　　金：国家科技支撑项目中国2型糖尿病患者肿瘤发生风险的流行病学研究(2013BAI09B13)。

摘　　要：目的评价甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)、甘油三酯葡萄糖简易指数(TyG指数)、非高密度脂蛋白胆固醇(non-HDL-C)对中老年女性代谢综合征(MS)发病风险的预测价值。方法2011年-2014年开展队列研究,纳入40周岁及以上大连社区女性居民2098例。通过二元Logistic回归模型分析TG/HDL-C、TyG指数、non-HDL-C与新诊断MS的关系,通过受试者工作特征(ROC)曲线分析3个指标对MS发病的预测价值。结果随访新诊断MS 363例(17.30%)。二元Logistic回归分析显示TG/HDL-C、TyG指数、non-HDL-C升高均是MS发生的独立危险因素(OR=2.297,95%CI 1.822~2.897,OR=3.370,95%CI 2.515~4.516,OR=1.555,95%CI 1.367~1.770,均P<0.01)。ROC曲线分析显示3个指标预测MS发病的AUC分别为0.721、0.708、0.614(均P<0.05),合适切点为0.70、8.49、4.06。TG/HDL-C、TyG指数的AUC大于non-HDL-C(Z=6.113,Z=5.819,均P<0.01)。结论中老年女性TG/HDL-C、TyG指数、non-HDL-C升高是3年后MS发病的独立危险因素,TG/HDL-C、TyG指数对MS发病有较好的预测价值。Objective To investigate the predictive values of TG/HDL-C,TyG index and non-HDL-C for incidence risk of metabolic syndrome(MS)in middle-aged and elderly women.Methods A cohort study was performed from 2011 to 2014 in communities in Dalian by recruiting 2,098 female residents aged≥40 years.Binary logistic regression model was used to analyze the relationship between TG/HDL-C,TyG index,non-HDL-C and MS of new diagnosis.ROC curve was built in three indicators for their predictive values in MS.Results Totally 363 MS cases(17.30%)were diagnosed from follow-up participants(n=2,098).Binary logistic regression analysis showed that elevated TG/HDL-C,TyG index and non-HDL-C were independent risk factors in MS(OR=2.297,95%CI 1.822-2.897,OR=3.370,95%CI 2.515-4.516,OR=1.555,95%CI 1.367-1.770,P<0.01).AUC of three indicators was 0.721,0.708 and 0.614 respectively in predicting MS(P<0.05),and optimal cut-off value was 0.70,8.49 and 4.06.AUC was larger in both TG/HDL-C and TyG index than in non-HDL-C(Z=6.113,Z=5.819,all P<0.01).Conclusion Higher TG/HDL-C,TyG index and non-HDL-C for three years were independent risks of MS in middle-aged and elderly women.TG/HDL-C and TyG index showed good predictions for MS.

关 键 词：代谢综合征 甘油三酯类 胆固醇 HDL 因素分析 统计学 

分 类 号：R589[医药卫生—内分泌]