All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors  

作　　者：Qin He Hazel McLellan Petra C.Boevink Paul R.J.Birch 

机构地区：[1]Key Laboratory of Horticultural Plant Biology(HZAU),Ministry of Education,Key Laboratory of Potato Biology and Biotechnology(HZAU),Ministry of Agriculture and Rural Affairs,Huazhong Agricultural University,Wuhan,Hubei 430070,China [2]Division of Plant Sciences,School of Life Sciences,University of Dundee(at JHI),Invergowrie,Dundee DD25DA,UK [3]Cell and Molecular Sciences,James Hutton Institute,Invergowrie,Dundee DD25DA,UK [4]These authors contributed equally to this article.

出　　处：《Plant Communications》2020年第4期1-12,共12页植物通讯（英文）

基　　金：support from the Biotechnology and Biological Sciences Research Council grants BB/P020569/1,BB/N009967/1,and BB/L026880/1;the ERC-Advanced grant PathEVome(787764);the Scottish Government Rural and Environment Science and Analytical Services Division.Q.H.is grateful for the Project 2662020YLQD001;supported by the Fundamental Research Funds for the Central Universities and Research Start Fund 105/11042010004 for High-Level talents in Huazhong Agricultural University,China.

摘　　要：The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant pathogen.Here,we review intracellular effectors from filamentous(fungal and oomycete)phytopathogens and the host proteins and processes that are targeted to promote disease.We cover contrasting virulence strategies and effector modes of action.Filamentous pathogen effectors alter the fates of host proteins that they target,changing their stability,their activity,their location,and the protein partners with which they interact.Some effectors inhibit target activity,whereas others enhance or utilize it,and some target multiple host proteins.We discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support susceptibility.We also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens,including those representing different kingdoms of life.

关 键 词：EFFECTORS FUNGI OOMYCETE immunity defense susceptibility factor 

分 类 号：Q94[生物学—植物学]