老挝丰沙里省岳乌县疟疾流行情况调查  

Investigation of the prevalence of malaria in Yue Wu County,Phongsaly Province,Laos

作　　者：李许珍 吴林波 张苍林[1] 徐艳春[1] Phanviengxay Khammavong Phoutnalong Vilay Hao Phommasa 杨锐[1] LI Xu-zhen;WU Lin-bo;ZHANG Cang-lin;XU Yan-chun;Phanviengxay Khammavong;Phoutnalong Vilay;Hao Phommasa;YANG Rui(Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research Yunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and Control of Yunnan Institute of Parasitic Diseases Puer,Yunnan 665000,China;National Malaria Centre,Lao People's Democratic Republic;Department of Health,Phongsaly Province,Lao Peoples Democratic Republic)

机构地区：[1]云南省虫媒传染病防控研究重点实验室,云南公共卫生与疾病防控协同创新中心,云南省寄生虫病防治所,云南普洱665000 [2]老挝人民民主共和国国家疟疾中心 [3]老挝人民民主共和国丰沙里省卫生厅

出　　处：《中国病原生物学杂志》2021年第8期969-970,974,共3页Journal of Pathogen Biology

基　　金：云南省虫媒传染病防控关键技术创新团队(培育)基金项目(No.2019HC010);面向南亚东南亚热带病国际科技人员交流与教育培训基地基金项目(No.20181A106)。

摘　　要：目的调查老挝丰沙里省岳乌县疟疾流行情况,为当地消除疟疾措施的制定提供依据。方法选取老挝丰沙里省岳乌县Loum村,采用诱蚊灯采集蚊虫,采用巢氏PCR方法检测疟疾主要媒介按蚊感染疟原虫子孢子;采集岳乌县当地居民滤纸血,采用巢式PCR法检测疟原虫感染情况。结果共捕获按蚊9种1 735只,其中,中华按蚊占捕获按蚊总数的87.67%(1521/1735),属于当地优势按蚊蚊种,密度为31.69只/(灯·夜)。中华按蚊间日疟子孢子阳性率0.52%(7/1340),微小按蚊间日疟子孢子阳性率75%(3/4)。当地健康人群疟原虫带虫率0.23%(1/433)。结论老挝岳乌县疟疾媒介种类丰富,疟疾带虫率较高,健康人群有疟原虫感染,存在疟疾暴发或流行风险,建议当地卫生部门加强对疟疾媒介及病例的监测。Objective To investigate the prevalence of malaria in Yuewu County, Phongsaly Province, Laos in order to provide evidence for the development of local malaria elimination measures. Methods Mosquitoes were collected by light traps in the Village of Loum, Yuwu County, Phongsaly Province, Laos. Nested PCR was used to detect Plasmodium sporozoites in Anopheles mosquitoes, the main vector of malaria. Blood was collected from local residents in Yuewu County and prepared as smears on filter paper. Nested PCR was used to detect Plasmodium infection. Results A total of 1 735 Anopheles mosquitoes from 9 species were captured, with An. sinensis accounting for 87.67%(1 521/1 735). An. sinensis belonged to the dominant Anopheles species in the region, with a density of 31.69 individuals/(lamp/night). An. sinensis tested positive for spores at a rate of 0.52%(7/1 340), and An. minimus tested positive at a rate of 75%(3/4). Carriage of Plasmodium in the healthy local population was 0.23%(1/433). Conclusion In Laowuxian County, Laos, malaria vectors are abundant and they carry malaria at a high rate. The healthy population is infected with Plasmodium, and there is a risk of a malaria outbreak or epidemic. The local health department should enhance the surveillance of malaria vectors and cases.

关 键 词：疟疾媒介 疟原虫带虫率 疟原虫子孢子 老挝 

分 类 号：R531.3[医药卫生—内科学]