铜绿假单胞菌群体感应系统las/rhl蛋白的研制现状  

Advance in studies on las/rhl of Pseudomonas aeruginosa

作　　者：欧兴坤 李文桂[1] OU Xing-kun;LI Wen-gui(Institute of Infections and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院传染病寄生虫病研究所,重庆400016

出　　处：《中国病原生物学杂志》2021年第8期988-990,F0003,F0004,共5页Journal of Pathogen Biology

基　　金：重庆市科委地方病重大专项(No.2008AB5055,2008AB5008,2008AB5054)。

摘　　要：铜绿假单胞菌是一种广泛存在于环境中的革兰阴性条件致病菌,常导致免疫功能受损患者的难治性感染,针对铜绿假单胞菌群体感应系统开发新的感染防治途径是目前的研究热点之一。本文对铜绿假单胞菌群体感应系统las/rhl蛋白的研制现状进行综述。Pseudomonas aeruginosa is a gram-negative opportunistic pathogen widely distributed in the environment, which often leads to refractory infection in patients with impaired immune function. Quorum-sensing-interference is one of the most intensively studied strategies for controlling disease caused by P. aeruginosa. This article reviewed the status of research on the las/rhl of P. aeruginosa quorum-sensing.

关 键 词：铜绿假单胞菌 LasR蛋白 RhlR蛋白 N-酰基高丝氨酸内酯 综述 

分 类 号：R378.991[医药卫生—病原生物学]